Within the potassium ion channel family, calcium activated potassium (KCa) channels are
unique in their ability to couple intracellular Ca2+ signals to membrane potential variations …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by selective loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain …

What happens precociously to the brain destined to develop Alzheimer's Disease (AD) still
remains to be elucidated and this is one reason why effective AD treatments are missing …

Transient changes in the activity of midbrain dopamine neurons encode an error signal that
contributes to associative learning. Although considerable attention has been devoted to the …

Dopamine (DA) midbrain neurons project to several striatal and cortical target areas and are
essentially involved in a puzzling variety of important brain functions such as action …

At least 70% of the afferents to substantia nigra dopaminergic neurons are GABAergic. The
vast majority of these arise from the neostriatum, the external globus pallidus and the …

Potassium channels are tetrameric membrane proteins that selectively conduct K+ across
cellular membranes. With 78 family members, K+ channels make up about half of the …

Calcium-activated potassium channels modulate calcium signaling cascades and
membrane potential in both excitable and non-excitable cells. In this article we will review …

Small conductance calcium-activated potassium (SK or K Ca 2) channels link intracellular
calcium transients to membrane potential changes. SK channel subtypes present different …

Little is known about the voltage-dependent potassium currents underlying spike
repolarization in midbrain dopaminergic neurons. Studying mouse substantia nigra pars …