Mesenchymal stem cells for neurological disorders

A Andrzejewska, S Dabrowska, B Lukomska… - Advanced …, 2021 - Wiley Online Library
Neurological disorders are becoming a growing burden as society ages, and there is a
compelling need to address this spiraling problem. Stem cell‐based regenerative medicine …

Chemically engineering cells for precision medicine

Y Wang, Z Li, F Mo, TJ Chen-Mayfield, A Saini… - Chemical Society …, 2023 - pubs.rsc.org
Cell-based therapy holds great potential to address unmet medical needs and revolutionize
the healthcare industry, as demonstrated by several therapeutics such as CAR-T cell …

Re-engineering extracellular vesicles as smart nanoscale therapeutics

JPK Armstrong, MN Holme, MM Stevens - ACS nano, 2017 - ACS Publications
In the past decade, extracellular vesicles (EVs) have emerged as a key cell-free strategy for
the treatment of a range of pathologies, including cancer, myocardial infarction, and …

[HTML][HTML] Advances in regenerative stem cell therapy in androgenic alopecia and hair loss: Wnt pathway, growth-factor, and mesenchymal stem cell signaling impact …

P Gentile, S Garcovich - Cells, 2019 - mdpi.com
The use of stem cells has been reported to improve hair regrowth in several therapeutic
strategies, including reversing the pathological mechanisms, that contribute to hair loss …

Manufacturing of primed mesenchymal stromal cells for therapy

JQ Yin, J Zhu, JA Ankrum - Nature biomedical engineering, 2019 - nature.com
Mesenchymal stromal cells (MSCs) for basic research and clinical applications are
manufactured and developed as unique cell products by many different manufacturers and …

Mesenchymal stem cells: immune evasive, not immune privileged

JA Ankrum, JF Ong, JM Karp - Nature biotechnology, 2014 - nature.com
The diverse immunomodulatory properties of mesenchymal stem/stromal cells (MSCs) may
be exploited for treatment of a multitude of inflammatory conditions. MSCs have long been …

[PDF][PDF] Mesenchymal stromal cells: sensors and switchers of inflammation

ME Bernardo, WE Fibbe - Cell stem cell, 2013 - cell.com
In addition to their stem/progenitor properties, mesenchymal stromal cells (MSCs) possess
broad immunoregulatory properties that are being investigated for potential clinical …

[HTML][HTML] Homing and migration of mesenchymal stromal cells: how to improve the efficacy of cell therapy?

A De Becker, I Van Riet - World journal of stem cells, 2016 - ncbi.nlm.nih.gov
Mesenchymal stromal cells (MSCs) are currently being investigated for use in a wide variety
of clinical applications. For most of these applications, systemic delivery of the cells is …

[HTML][HTML] Immunobiology of mesenchymal stem cells

S Ma, N Xie, W Li, B Yuan, Y Shi, Y Wang - Cell Death & Differentiation, 2014 - nature.com
Mesenchymal stem cells (MSCs) can be isolated from almost all tissues and effectively
expanded in vitro. Although their true in situ properties and biological functions remain to be …

[HTML][HTML] The challenges and promises of allogeneic mesenchymal stem cells for use as a cell-based therapy

J Zhang, X Huang, H Wang, X Liu, T Zhang… - Stem cell research & …, 2015 - Springer
Mesenchymal stem cells (MSCs) are ideal for cell-based therapy in various inflammatory
diseases because of their immunosuppressive and tissue repair properties. Moreover, their …