Cardiac fibrosis is mediated by the activation of resident cardiac fibroblasts, which
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …

Cardiomyocytes exit the cell cycle and become terminally differentiated soon after birth.
Therefore, in the adult heart, instead of an increase in cardiomyocyte number, individual …

Introduction Myocardial infarction (MI) is the leading cause of congestive heart failure and
mortality. Hypoxia is an important trigger in the cardiac remodeling of the myocardium in the …

This review aims to provide a translational perspective on recent developments in heart
failure with preserved ejection fraction (HFpEF), linking mechanistic insights to potential …

Mesenchymal stem cells (MSCs) reside in the perivascular niche of many organs, including
kidney, lung, liver, and heart, although their roles in these tissues are poorly understood …

Atrial fibrillation (AF)—the most common arrhythmia—significantly increases the risk of
stroke and heart failure. Although catheter ablation can restore normal heart rhythms …

Atrial fibrillation (AF) is associated with structural, electrical, and contractile remodeling of
the atria. Development and progression of atrial fibrosis is the hallmark of structural …

In response to stress, the heart undergoes extensive cardiac remodeling that results in
cardiac fibrosis and pathological growth of cardiomyocytes (hypertrophy), which contribute …

Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …

The understanding of atrial fibrillation (AF) evolved from a sole rhythm disturbance towards
the complex concept of a cardiomyopathy based on arrhythmia substrates. There is …