Computational modeling of the effect of skin pinch and stretch on subcutaneous injection of monoclonal antibodies using autoinjector devices
Subcutaneous injection of monoclonal antibodies (mAbs) has experienced unprecedented
growth in the pharmaceutical industry due to its benefits in patient compliance and cost …
growth in the pharmaceutical industry due to its benefits in patient compliance and cost …
Modeling drug transport and absorption in subcutaneous injection of monoclonal antibodies: Impact of tissue deformation, devices, and physiology
The pharmaceutical industry has experienced a remarkable increase in the use of
subcutaneous injection of monoclonal antibodies (mAbs), attributed mainly to its advantages …
subcutaneous injection of monoclonal antibodies (mAbs), attributed mainly to its advantages …
Stabilized isogeometric formulation of the multi-network poroelasticity and transport model (mpet2) for subcutaneous injection of monoclonal antibodies
The MPET 2 model couples the multi-network poroelastic theory (MPET) with solute
transport equations and provides predictions of the material deformation, fluid dynamics …
transport equations and provides predictions of the material deformation, fluid dynamics …
A multi-scale numerical study of monoclonal antibodies uptake by initial lymphatics after subcutaneous injection
This paper studies the transport of monoclonal antibodies through skin tissue and initial
lymphatics, which impacts the pharmacokinetics of monoclonal antibodies. Our model …
lymphatics, which impacts the pharmacokinetics of monoclonal antibodies. Our model …
[HTML][HTML] Multi-field modeling and computational optimization of a subcutaneous insulin injection port
L Zoboli, F Luppino, D Bianchi, A Nannei, L Lazzarotti… - Materials & Design, 2024 - Elsevier
The present study proposes an advanced multi-field modeling approach to optimize in silico
subcutaneous insulin release. We introduce a generalized fluid-pharmacokinetics …
subcutaneous insulin release. We introduce a generalized fluid-pharmacokinetics …
A MPET2-mPBPK model for subcutaneous injection of biotherapeutics with different molecular weights: From local scale to whole-body scale
Abstract Background and Objective: Subcutaneous injection of biotherapeutics has attracted
considerable attention in the pharmaceutical industry. However, there is limited …
considerable attention in the pharmaceutical industry. However, there is limited …
Poroelastic Characterization and Modeling of Subcutaneous Tissue Under Confined Compression
J Barsimantov, J Payne, M de Lucio, M Hakim… - Annals of Biomedical …, 2024 - Springer
Subcutaneous tissue mechanics are important for drug delivery. Yet, even though this
material is poroelastic, its mechanical characterization has focused on its hyperelastic …
material is poroelastic, its mechanical characterization has focused on its hyperelastic …