Advancing symptom science through symptom cluster research: expert panel proceedings and recommendations

C Miaskowski, A Barsevick, A Berger… - JNCI: Journal of the …, 2017 - academic.oup.com
An overview of proceedings, findings, and recommendations from the workshop on
“Advancing Symptom Science Through Symptom Cluster Research” sponsored by the …

The role of glutamate and GABA in cognitive dysfunction in schizophrenia and mood disorders–A systematic review of magnetic resonance spectroscopy studies

M Reddy-Thootkur, NV Kraguljac, AC Lahti - Schizophrenia research, 2022 - Elsevier
Epidemiologic, genetic, and neurobiological studies suggest considerable overlap between
schizophrenia and mood disorders. Importantly, both disorders are associated with a broad …

Neuropsychological and functional outcomes in recent-onset major depression, bipolar disorder and schizophrenia-spectrum disorders: a longitudinal cohort study

RSC Lee, DF Hermens, SL Naismith… - Translational …, 2015 - nature.com
Functional disability is the lead contributor to burden of mental illness. Cognitive deficits
frequently limit functional recovery, although whether changes in cognition and disability are …

Biological subtyping of psychiatric syndromes as a pathway for advances in drug discovery and personalized medicine

W Zhang, JA Sweeney, JR Bishop, Q Gong… - Nature Mental …, 2023 - nature.com
Every common psychiatric syndrome is genetically, neurobiologically and clinically
heterogeneous. This heterogeneity may reflect the dimensional variability of a single illness …

Glutamatergic and N-acetylaspartate metabolites in bipolar disorder: a systematic review and meta-analysis of proton magnetic resonance spectroscopy studies

J Chabert, E Allauze, B Pereira, C Chassain… - International Journal of …, 2022 - mdpi.com
The exact neurobiological mechanisms of bipolar disorder (BD) remain unknown. However,
some neurometabolites could be implicated, including Glutamate (Glu), Glutamine (Gln) …

Abnormality in glutamine–glutamate cycle in the cerebrospinal fluid of cognitively intact elderly individuals with major depressive disorder: a 3-year follow-up study

K Hashimoto, D Bruno, J Nierenberg… - Translational …, 2016 - nature.com
Major depressive disorder (MDD), common in the elderly, is a risk factor for dementia.
Abnormalities in glutamatergic neurotransmission via the N-methyl-d-aspartate receptor …

Glutamatergic neurometabolite levels in bipolar disorder: A systematic review and meta-analysis of proton magnetic resonance spectroscopy studies

H Ino, S Honda, K Yamada, N Horita, S Tsugawa… - Biological Psychiatry …, 2023 - Elsevier
Background The glutamatergic system is thought to play an important role in the
pathophysiology of bipolar disorder (BD). While there has been an increase in proton …

Parcellating cognitive heterogeneity in early psychosis-spectrum illnesses: a cluster analysis

JJ Crouse, AA Moustafa, SER Bogaty, IB Hickie… - Schizophrenia …, 2018 - Elsevier
Cognitive impairment is argued to represent a core feature of psychosis-spectrum illnesses.
However, within-diagnosis heterogeneity is common, and risk factors for poor cognition …

Data-driven cognitive phenotypes in subjects with bipolar disorder and their clinical markers of severity

FD Rabelo-da-Ponte, FM Lima… - Psychological …, 2022 - cambridge.org
BackgroundSubjects with bipolar disorder (BD) show heterogeneous cognitive profile and
that not necessarily the disease will lead to unfavorable clinical outcomes. We aimed to …

Hippocampal glutamate is increased and associated with risky drinking in young adults with major depression

DF Hermens, KM Chitty, RSC Lee, A Tickell… - Journal of affective …, 2015 - Elsevier
Background Risky drinking in young people is harmful, highly prevalent and often
complicated by comorbid mental health problems that compound alcohol-induced …