This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily
of transporter proteins and their roles in human cells. The SLC superfamily currently …

Calcium, phosphate, and magnesium are multivalent cations that are important for many
biologic and cellular functions. The kidneys play a central role in the homeostasis of these …

Vascular calcification contributes to the high risk of cardiovascular mortality in chronic kidney
disease (CKD) patients. Dysregulation of calcium (Ca) and phosphate (P) metabolism is …

Inorganic phosphate (Pi) plays a critical function in many tissues of the body: for example, as
part of the hydroxyapatite in the skeleton and as a substrate for ATP synthesis. Pi is the main …

Soft-tissue calcification is a prominent feature in both chronic kidney disease (CKD) and
experimental Klotho deficiency, but whether Klotho deficiency is responsible for the …

Plant phosphate (Pi) transporters mediate the uptake and translocation of this nutrient within
plants. A total of 13 sequences in the rice (Oryza sativa) genome can be identified as …

In mammals, phosphate balance is maintained by influx and efflux via the intestines,
kidneys, bone, and soft tissue, which involves multiple sodium/phosphate (Na+/Pi) …

Inorganic phosphate (Pi) is an abundant element in the body and is essential for a wide
variety of key biological processes. It plays an essential role in cellular energy metabolism …

Familial idiopathic basal ganglia calcification (IBGC) is a genetic condition with a wide
spectrum of neuropsychiatric symptoms, including parkinsonism and dementia. Here, we …

Transport of inorganic phosphate (Pi) across the plasma membrane is essential for normal
cellular function. Members of two families of SLC proteins (SLC20 and SLC34) act as Na+ …