Transcription factors (TFs) represent key biological players in diseases including cancer,
autoimmunity, diabetes and cardiovascular disease. However, outside nuclear receptors …

Abstract Salvia miltiorrhiza Burge (Danshen) is an eminent medicinal herb that possesses
broad cardiovascular and cerebrovascular protective actions and has been used in Asian …

Excessive mitochondrial ROS production has been causally linked to the pathophysiology of
aging in the heart and other organs, and plays a deleterious role in several age-related …

Gallic acid (GA) has been reported to have beneficial effects on cancer, vascular
calcification, and diabetes-induced myocardial dysfunction. We hypothesized that GA …

Cardiotoxicity is a well-known side effect of doxorubicin (DOX), but the mechanisms leading
to this phenomenon are still not completely clear. Prediction of drug-induced dysfunction …

Polypyrrole (Ppy) is an electroconductive polymer used in various applications, including in
vitro experiments with cell cultures under electrical stimulation (ES). Ppy can be applied in …

Abstract Interferon regulatory factor 8 (IRF8) is known to affect the innate immune response,
for example, by regulating the differentiation and function of immune cells. However …

Gallic acid, a type of phenolic acid, has been shown to have beneficial effects in
inflammation, vascular calcification, and metabolic diseases. The present study was aimed …

Uncovering cellular responses from heterogeneous genomic data is crucial for molecular
medicine in particular for drug safety. This can be realized by integrating the molecular …

Interferon regulatory factor 1 (IRF1), a critical member of the IRF family, was previously
shown to be associated with the immune system and to be involved in apoptosis and tumor …