Emerging evidence indicates that the detection and clearance of cancer cells via
phagocytosis induced by innate immune checkpoints play significant roles in tumor …

Cancer immunotherapies targeting adaptive immune checkpoints have substantially
improved patient outcomes across multiple metastatic and treatment-refractory cancer types …

Tumor-associated myeloid cells maintain immunosuppressive microenvironments within
tumors. Identification of myeloid-specific receptors to modulate tumor-associated …

The activating natural killer (NK)-cell receptor KIR3DS1 has been linked to the outcome of
various human diseases, including delayed progression of disease caused by human …

Natural killer cells (NK cells) play an important role in innate immunity. NK cells recognize
self and nonself depending on the balance of activating receptors and inhibitory receptors …

Untreated HIV-1 infection typically progresses to AIDS within 10 years, but less than 1% of
infected individuals remain healthy and have normal CD4+ T cell counts and undetectable …

The expression level of HLA class-I proteins is known to influence pathological outcomes:
pathogens downregulate HLA to evade host immune responses, host inflammatory …

The leukocyte immunoglobulin-like receptor (LILR) family comprises a set of paired
immunomodulatory receptors expressed among human myeloid and lymphocyte cell …

Abstract Killer Ig-like receptors (KIRs) are innate immune receptors expressed by NK and T
cells classically associated with the detection of missing self through loss of their respective …

Immune checkpoint blockade is a compelling approach in tumor immunotherapy. Blocking
inhibitory pathways in T cells has demonstrated clinical efficacy in different types of cancer …