As the population ages, the economic and societal impacts of neurodegenerative and
neuropsychiatric disorders are expected to rise sharply. Like dementia, late-life depressive …

Technical advances have facilitated the exploration of factors related to geriatric depression
and have helped generate novel biological and psychosocial treatment approaches. This …

Objective: White matter abnormalities may interfere with limbic cortical balance and lead to
chronic depressive syndromes. The authors used diffusion tensor imaging to test the …

Brain-derived neurotrophic factor (BDNF), one of the major neurotrophic factors, plays an
important role in the maintenance and survival of neurons, synaptic integrity, and synaptic …

Objectives Late-life major depression (LLD) is characterized by distinct epidemiologic and
psychosocial factors, as well as medical comorbidities that are associated with specific …

The anterior cingulate cortex, amygdala and hippocampus form part of an interconnected
prefrontal neocortical and limbic archicortical network that is dysregulated in major …

In this study, we explored to what extent brain abnormalities can be identified in specific
brain structures of patients suffering from late onset depression. We examined the structural …

BACKGROUND: Cerebrovascular disease plays an important role in depressive disorder,
especially in older adults. An understanding of vascular function in depression is important …

Ahdidan J, Hviid LB, Chakravarty MM, Ravnkilde B, Rosenberg R, Rodell A, Stødkilde‐
Jørgensen H, Videbech P. Longitudinal MR study of brain structure and hippocampus …

Abstract Objective Positron Emission Tomography (PET) studies of cerebral glucose
metabolism have demonstrated sensitivity in evaluating the functional neuroanatomy of …