Overview of recent advancements in the iontophoretic drug delivery to various tissues and organs

AM Helmy - Journal of Drug Delivery Science and Technology, 2021 - Elsevier
Iontophoresis is a physical drug delivery enhancing technique that was introduced at the
beginning of the preceding century. For decades, iontophoresis research was focused on …

Local delivery of molecules from a nanopipette for quantitative receptor mapping on live cells

B Babakinejad, P Jönsson, A Lopez Cordoba… - Analytical …, 2013 - ACS Publications
Using nanopipettes to locally deliver molecules to the surface of living cells could potentially
open up studies of biological processes down to the level of single molecules. However, in …

Coupling multielectrode array recordings with silver labeling of recording sites to study cervical spinal network connectivity

KA Streeter, MD Sunshine, SR Patel… - Journal of …, 2017 - journals.physiology.org
Midcervical spinal interneurons form a complex and diffuse network and may be involved in
modulating phrenic motor output. The intent of the current work was to enable a better …

Glucose-monitoring neurons in the mediodorsal prefrontal cortex

B Nagy, I Szabó, S Papp, G Takács, C Szalay, Z Karádi - Brain research, 2012 - Elsevier
The mediodorsal prefrontal cortex (mdPFC), a key structure of the limbic neural circuitry,
plays important roles in the central regulation of feeding. As an integrant part of the forebrain …

Quantitative analysis of iontophoretic drug delivery from micropipettes

DC Kirkpatrick, LR Walton, MA Edwards, RM Wightman - Analyst, 2016 - pubs.rsc.org
Microiontophoresis is a drug delivery method in which an electric current is used to eject
molecular species from a micropipette. It has been primarily utilized for neurochemical …

Noradrenaline and acetylcholine responsiveness of glucose-monitoring and glucose-insensitive neurons in the mediodorsal prefrontal cortex

B Nagy, I Szabó, B Csetényi, E Hormay, S Papp… - Brain research, 2014 - Elsevier
The mediodorsal prefrontal cortex (mdPFC), as part of the forebrain glucose-monitoring
(GM) system, plays important role in several regulatory processes to control the internal state …

Evaluation of drug concentrations delivered by microiontophoresis

DC Kirkpatrick, RM Wightman - Analytical chemistry, 2016 - ACS Publications
Microiontophoresis uses an electric current to eject a drug solution from a glass capillary
and is often utilized for targeted delivery in neurochemical investigations. The amount of …

Separation of electrophysiologically distinct neuronal populations in the rat hippocampus for neuropharmacological testing under in vivo conditions

Z Bali, D Budai, I Hernádi - Acta Biologica Hungarica, 2014 - akjournals.com
Microiontophoresis combined with extracellular spike recording is an excellent method for
investigating local neuropharmacological effects under in vivo conditions. However, its …

Yohimbine acts as a putative in vivo α2A/D-antagonist in the rat prefrontal cortex

P Kovács, I Hernádi - Neuroscience letters, 2006 - Elsevier
Yohimbine has been widely used as α2-adrenergic receptor antagonist in
neurophysiological research and in clinical therapy. In this study, we provide in vivo …

The application of in vivo microiontophoresis for the investigation of mast cell–neuron interactions in the rat brain

Z Kőszegi, P Kovács, M Wilhelm, T Atlasz… - Journal of biochemical …, 2006 - Elsevier
Although mast cells are immune cells of hematopoietic origin, they can be found in parts of
the central nervous system of many mammalian species. In the rat brain they are located in …