Chemical Biology of H2S Signaling through Persulfidation

MR Filipovic, J Zivanovic, B Alvarez… - Chemical …, 2018 - ACS Publications
Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …

Kinetics and mechanisms of thiol–disulfide exchange covering direct substitution and thiol oxidation-mediated pathways

P Nagy - Antioxidants & redox signaling, 2013 - liebertpub.com
Significance: Disulfides are important building blocks in the secondary and tertiary structures
of proteins, serving as inter-and intra-subunit cross links. Disulfides are also the major …

Adiponectin peptide alleviates oxidative stress and NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK/GSK-3β

H Liu, X Wu, J Luo, L Zhao, X Li, H Guo, H Bai… - Experimental …, 2020 - Elsevier
The effects of current treatment strategies for ischemic stroke are weakened by ischemia-
reperfusion (I/R) injury. Effective treatments targeting I/R injury are still insufficient …

New design of a disulfurating reagent: facile and straightforward pathway to unsymmetrical disulfanes by copper‐catalyzed oxidative cross‐coupling

X Xiao, M Feng, X Jiang - Angewandte Chemie International …, 2016 - Wiley Online Library
A novel reagent, which introduces two sulfur atoms in one step, was designed and used for
the construction of diverse disulfanes by copper‐catalyzed oxidative cross‐coupling under …

Copper (I)‐Catalyzed Asymmetric Interrupted Kinugasa Reaction: Synthesis of α‐Thiofunctional Chiral β‐Lactams

J Qi, F Wei, S Huang, CH Tung, Z Xu - Angewandte Chemie, 2021 - Wiley Online Library
A copper (I)‐catalyzed asymmetric, three‐component interrupted Kinugasa reaction has
been developed. Diverse chiral sulfur‐containing chiral β‐lactams with two consecutive …

Understanding the pKa of Redox Cysteines: The Key Role of Hydrogen Bonding

G Roos, N Foloppe, J Messens - Antioxidants & redox signaling, 2013 - liebertpub.com
Many cellular functions involve cysteine chemistry via thiol–disulfide exchange pathways.
The nucleophilic cysteines of the enzymes involved are activated as thiolate. A thiolate is …

[图书][B] Chemical reagents for protein modification

RL Lundblad - 2004 - taylorfrancis.com
Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

Access to polysulfides through photocatalyzed dithiosulfonylation

X Ren, Q Ke, Y Zhou, J Jiao, G Li, S Cao… - Angewandte …, 2023 - Wiley Online Library
In this study, we outline a general method for photocatalyzed difunctionalization of alkenes,
a diene, alkynes, 1, 3‐enynes, and [1.1. 1] propellane using dithiosulfonate reagents (ArSO2 …

Reversible cysteine oxidation in hydrogen peroxide sensing and signal transduction

S García-Santamarina, S Boronat, E Hidalgo - Biochemistry, 2014 - ACS Publications
Activation of redox cascades through hydrogen peroxide-mediated reversible cysteine
oxidation is a major mechanism for intracellular signaling. Understanding why some …

Biotin conjugated organic molecules and proteins for cancer therapy: A review

S Maiti, P Paira - European journal of medicinal chemistry, 2018 - Elsevier
The main transporter for biotin is sodium dependent multivitamin transporter (SMVT), which
is overexpressed in various aggressive cancer cell lines such as ovarian (OV 2008, ID8) …