Innovations in monoclonal antibody-based multipurpose prevention technology (MPT) for the prevention of sexually transmitted infections and unintended pregnancy
S Dohadwala, MT Geib, JA Politch… - … in Reproductive Health, 2024 - frontiersin.org
Monoclonal antibodies (mAbs) are currently being produced for a number of clinical
applications including contraception and the prevention of sexually transmitted infections …
applications including contraception and the prevention of sexually transmitted infections …
Virtual populations for quantitative systems pharmacology models
Quantitative systems pharmacology (QSP) places an emphasis on dynamic systems
modeling, incorporating considerations from systems biology modeling and …
modeling, incorporating considerations from systems biology modeling and …
Creating a Roadmap to Quantitative Systems Pharmacology–Informed Rare Disease Drug Development: A Workshop Report
JPF Bai, AL Stinchcomb, J Wang, J Earp… - Clinical …, 2024 - Wiley Online Library
One of the goals of the Accelerating Rare Disease Cures (ARC) program in the Center for
Drug Evaluation and Research (CDER) at the US Food and Drug Administration (FDA) is the …
Drug Evaluation and Research (CDER) at the US Food and Drug Administration (FDA) is the …
Mechanistically weighted metric to predict in vivo antibody-receptor occupancy: an analytical approach
In situ clinical measurement of receptor occupancy (RO) is challenging, particularly for solid
tumors, necessitating the use of mathematical models that predict tumor receptor occupancy …
tumors, necessitating the use of mathematical models that predict tumor receptor occupancy …