Multifunctional roles of the mammalian CCR4–NOT complex in physiological phenomena
YT Shirai, T Suzuki, M Morita, A Takahashi… - Frontiers in …, 2014 - frontiersin.org
The carbon catabolite repression 4 (CCR4)–negative on TATA-less (NOT) complex serves
as one of the major deadenylases of eukaryotes. Although it was originally identified and …
as one of the major deadenylases of eukaryotes. Although it was originally identified and …
Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics
INTRODUCTION Understanding the differentiation of stem cells into the vast amount of cell
types that form the human body is a central problem of basic and medical science. The …
types that form the human body is a central problem of basic and medical science. The …
Deadenylation of mRNA by the CCR4–NOT complex in Drosophila: molecular and developmental aspects
C Temme, M Simonelig, E Wahle - Frontiers in genetics, 2014 - frontiersin.org
Controlled shortening of the poly (A) tail of mRNAs is the first step in eukaryotic mRNA decay
and can also be used for translational inactivation of mRNAs. The CCR4–NOT complex is …
and can also be used for translational inactivation of mRNAs. The CCR4–NOT complex is …
Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria
Planarian flatworms regenerate every organ after amputation. Adult pluripotent stem cells
drive this ability, but how injury activates and directs stem cells into the appropriate lineages …
drive this ability, but how injury activates and directs stem cells into the appropriate lineages …
RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation
The CCR4-NOT complex acts as a central player in the control of mRNA turnover and
mediates accelerated mRNA degradation upon HDAC inhibition. Here, we explored …
mediates accelerated mRNA degradation upon HDAC inhibition. Here, we explored …
Decoding stem cells: an overview on planarian stem cell heterogeneity and lineage progression
Planarians are flatworms capable of whole-body regeneration, able to regrow any missing
body part after injury or amputation. The extraordinary regenerative capacity of planarians is …
body part after injury or amputation. The extraordinary regenerative capacity of planarians is …
[PDF][PDF] Rebuilding a planarian: from early signaling to final shape
Why some animals can regenerate and others not has fascinated biologists since the first
examples of regeneration were reported. Although many animal phyla include species with …
examples of regeneration were reported. Although many animal phyla include species with …
Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians
In contrast to transcriptional regulation, the function of alternative splicing (AS) in stem cells
is poorly understood. In mammals, MBNL proteins negatively regulate an exon program …
is poorly understood. In mammals, MBNL proteins negatively regulate an exon program …
Epigenetic analyses of planarian stem cells demonstrate conservation of bivalent histone modifications in animal stem cells
Planarian flatworms have an indefinite capacity to regenerate missing or damaged body
parts owing to a population of pluripotent adult stems cells called neoblasts (NBs). Currently …
parts owing to a population of pluripotent adult stems cells called neoblasts (NBs). Currently …
Acetylation-dependent control of global poly (A) RNA degradation by CBP/p300 and HDAC1/2
Acetylation of histones and transcription-related factors is known to exert epigenetic and
transcriptional control of gene expression. Here we report that histone acetyltransferases …
transcriptional control of gene expression. Here we report that histone acetyltransferases …