Resource allocation affects the structure of microbiomes, including those associated with
living hosts. Understanding the degree to which this dependency determines interspecies …

The gut microbiome interacts with the host through complex networks that affect physiology
and health outcomes. It is becoming clear that these interactions can be measured across …

Metabolic interactions are fundamental to the assembly and functioning of microbiomes,
including those of plants. However, disentangling the molecular basis of these interactions …

The Escherichia coli genome‐scale metabolic model (GEM) is an exemplar systems biology
model for the simulation of cellular metabolism. Experimental validation of model predictions …

Our ability to predict, control, or design biological function is fundamentally limited by poorly
annotated gene function. This can be particularly challenging in non-model systems …

Expert curation is essential to capture knowledge of enzyme functions from the scientific
literature in FAIR open knowledgebases but cannot keep pace with the rate of new …

Predicting interspecies interactions is a key challenge in microbial ecology given that
interactions shape the composition and functioning of microbial communities. However …

The presence and role of microbes in human cancers has come full circle in the last century.
Tumors are no longer considered aseptic, but implications for cancer biology and oncology …

With the rapid progress in metabolomics and sequencing technologies, more data on the
metabolome of single microbes and their communities become available, revealing the …

The diversity and functional significance of microbiomes have become increasingly clear
through the extensive sampling of Earth's many habitats and the rapid adoption of new …