Cell migration is essential for physiological processes as diverse as development, immune
defence and wound healing. It is also a hallmark of cancer malignancy. Thousands of …

As the crucial non-cellular component of tissues, the extracellular matrix (ECM) provides
both physical support and signaling regulation to cells. Some ECM molecules provide a …

Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

The extracellular matrix (ECM) is an integral component of all organs and plays a pivotal
role in tissue homeostasis and repair. While the ECM was long thought to mostly have …

Hyaline cartilages, fibrocartilages and elastic cartilages play multiple roles in the human
body including bearing loads in articular joints and intervertebral discs, providing joint …

Cell walls are highly dynamic structures that provide mechanical support for plant cells
during growth, development and adaptation to a changing environment. Thus, it is important …

The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

Scar formation is a common consequence of skin injuries that lead to a wide range of
adverse effects including physical deformities and psychological disorders. Studies …

The fibrotic encapsulation of implants involves the mechanical activation of myofibroblasts
and of pro-fibrotic transforming growth factor beta 1 (TGF-β1). Here, we show that both …

Like the major theme of a Mozart concerto, the immense and pervasive extracellular matrix
drives each movement and ultimately closes the symphony, embracing a unique role as the …