Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
aggregation of ubiquitinated proteins in affected motor neurons. Recent studies have …

RNA binding proteins are critical to the maintenance of the transcriptome via controlled
regulation of RNA processing and transport. Alterations of these proteins impact multiple …

Proximal spinal muscular atrophy (SMA), a leading genetic cause of infant death worldwide,
is an early-onset, autosomal recessive neurodegenerative disease characterized by the loss …

The RNA-binding protein FUS/TLS, mutation in which is causative of the fatal motor neuron
disease amyotrophic lateral sclerosis (ALS), is demonstrated to directly bind to the U1 …

Mutations in the RNA binding protein FUS cause amyotrophic lateral sclerosis (ALS), a fatal
adult motor neuron disease. Decreased expression of SMN causes the fatal childhood motor …

Two motor neuron diseases, amyotrophic lateral sclerosis (ALS) and spinal muscular
atrophy (SMA), are caused by distinct genes involved in RNA metabolism, TDP‐43 and …

We previously reported the discovery of P7C3, an aminopropyl carbazole having
proneurogenic and neuroprotective properties in newborn neural precursor cells of the …

Mutations in the RNA binding protein fused in sarcoma/translated in liposarcoma (FUS/TLS)
cause amyotrophic lateral sclerosis (ALS). Although ALS-linked mutations in FUS often lead …

The fatal disease amyotrophic lateral sclerosis (ALS) is characterized by the loss of somatic
motor neurons leading to muscle wasting and paralysis. However, motor neurons in the …

Distal hereditary neuropathies and neuro motor diseases are complex neurological
phenotypes associated with pathogenic variants in a large number of genes, but in some the …