After a Turkish scientist took Nobel Prize due to his contributions to understand clock genes,
melatonin, closely related to these genes, may begin to shine. Melatonin, a hormone …

Pro-inflammatory systemic conditions that can cause neuroinflammation and subsequent
alterations in brain regions involved in emotional regulation have been suggested as an …

Melatonin is a potent endogenous free radical scavenger, actions that are independent of its
many receptor-mediated effects. In the last several years, hundreds of publications have …

In addition to its antioxidative effects melatonin acts through specific nuclear and plasma
membrane receptors. To date, two G-protein coupled melatonin membrane receptors, MT1 …

Abstract Melatonin (N‐acetyl‐5‐methoxytryptamine) is a molecule with a very wide
phylogenetic distribution from plants to man. In vertebrates, melatonin was initially thought to …

During the last 20 years, numerous clinical trials have examined the therapeutic usefulness
of melatonin in different fields of medicine. The objective of this article is to review, in depth …

In normal subjects, the secretion of melatonin, the pineal hormone that regulates the rhythm
of many functions, exhibits a circadian pattern synchronized with the day–night cycle. An …

Sleep disturbance is common in epilepsy, the nature of sleep disturbances in epilepsy is
diverse, and the etiologies are complex. Evidence suggests that having epilepsy and the …

Objective To evaluate the efficacy and safety of melatonin in the treatment of sleep onset
insomnia in children and adolescents. Methods Electronic databases and bibliographies of …

Purpose: Recently, melatonin has been associated with antiepileptic activity, most probably
because of its antioxidant activity as a free radical scavenger. This study aimed to expand …