Application of nanotechnology in thrombus therapy
S Zhou, W Zhao, J Hu, C Mao… - Advanced Healthcare …, 2023 - Wiley Online Library
A thrombus is a blood clot that forms in the lumen of an artery or vein, restricting blood flow
and causing clinical symptoms. Thrombosis is associated with many life‐threatening …
and causing clinical symptoms. Thrombosis is associated with many life‐threatening …
Maintenance of tight junction integrity in the absence of vascular dilation in the brain of mice exposed to ultra-high-dose-rate FLASH irradiation
BD Allen, MM Acharya, P Montay-Gruel… - Radiation …, 2020 - meridian.allenpress.com
Persistent vasculature abnormalities contribute to an altered CNS microenvironment that
further compromises the integrity of the blood-brain barrier and exposes the brain to a host …
further compromises the integrity of the blood-brain barrier and exposes the brain to a host …
Bone Marrow-Derived Alk1 Mutant Endothelial Cells and Clonally Expanded Somatic Alk1 Mutant Endothelial Cells Contribute to the Development of Brain …
We have previously demonstrated that deletion of activin receptor-like kinase 1 (Alk1) or
endoglin in a fraction of endothelial cells (ECs) induces brain arteriovenous malformations …
endoglin in a fraction of endothelial cells (ECs) induces brain arteriovenous malformations …
Endothelial surface translocation of mitochondrial PDCE2 involves the non-canonical secretory autophagy pathway: Putative molecular target for radiation-guided …
F Faqihi, MA Stoodley, LS McRobb - Experimental Cell Research, 2021 - Elsevier
Radiation has been proposed as a priming agent to induce discriminatory luminal
biomarkers for vascular targeting and drug delivery in disorders such as brain arteriovenous …
biomarkers for vascular targeting and drug delivery in disorders such as brain arteriovenous …
Externalization of Mitochondrial PDCE2 on Irradiated Endothelium as a Target for Radiation-Guided Drug Delivery and Precision Thrombosis of Pathological …
F Faqihi, MA Stoodley, LS McRobb - International Journal of Molecular …, 2022 - mdpi.com
Endothelial cells are highly sensitive to ionizing radiation, and exposure leads to multiple
adaptive changes. Remarkably, part of this response is the translocation of normally …
adaptive changes. Remarkably, part of this response is the translocation of normally …
The Evolution of Safe and Effective Coaguligands for Vascular Targeting and Precision Thrombosis of Solid Tumors and Vascular Malformations
F Faqihi, MA Stoodley, LS McRobb - Biomedicines, 2021 - mdpi.com
In cardiovascular and cerebrovascular biology, control of thrombosis and the coagulation
cascade in ischemic stroke, myocardial infarction, and other coagulopathies is the focus of …
cascade in ischemic stroke, myocardial infarction, and other coagulopathies is the focus of …
Targeting of externalized αB-crystallin on irradiated endothelial cells with pro-thrombotic vascular targeting agents: Potential applications for brain arteriovenous …
S Subramanian, Z Zhao, F Faqihi, GE Grau… - Thrombosis research, 2020 - Elsevier
Background Vascular targeting uses molecular markers on the surface of diseased
vasculature for ligand-directed drug delivery to induce vessel occlusion or destruction. In the …
vasculature for ligand-directed drug delivery to induce vessel occlusion or destruction. In the …
[图书][B] FLASH irradiation protects the central nervous system
BD Allen - 2023 - search.proquest.com
Radiotherapy has long been used to control tumor growth by causing ionization of cellular
macromolecules including DNA, RNA, lipids and proteins, leading to lethal or sublethal …
macromolecules including DNA, RNA, lipids and proteins, leading to lethal or sublethal …
[HTML][HTML] Brain arteriovenous malformations: A scoping review of experimental models
Background Brain arteriovenous malformations (bAVM) are one of the most complex
vascular lesions in humans. Their understanding and treatment have been possible through …
vascular lesions in humans. Their understanding and treatment have been possible through …