Functional nucleic acid sensors

J Liu, Z Cao, Y Lu - Chemical reviews, 2009 - ACS Publications
Sensors are devices that respond to physical or chemical stimuli and produce detectable
signals. 1r4 They are a critical extension of human perception of the world in many aspects …

Biologically active molecules with a “light switch”

G Mayer, A Heckel - Angewandte Chemie International Edition, 2006 - Wiley Online Library
Biologically active compounds which are light‐responsive offer experimental possibilities
which are otherwise very difficult to achieve. Since light can be manipulated very precisely …

Functional aptamers and aptazymes in biotechnology, diagnostics, and therapy

M Famulok, JS Hartig, G Mayer - Chemical reviews, 2007 - ACS Publications
Aptamers are single-stranded nucleic acid molecules that possess properties comparable to
those of protein monoclonal antibodies, and thus are clear alternatives to long established …

Nucleic acid aptamers: an emerging tool for biotechnology and biomedical sensing

TH Ku, T Zhang, H Luo, TM Yen, PW Chen, Y Han… - Sensors, 2015 - mdpi.com
Detection of small molecules or proteins of living cells provides an exceptional opportunity to
study genetic variations and functions, cellular behaviors, and various diseases including …

Natural and engineered nucleic acids as tools to explore biology

RR Breaker - Nature, 2004 - nature.com
RNA and DNA molecules can form complex, three-dimensional folded structures that have
surprisingly sophisticated functions, including catalysing chemical reactions and controlling …

Fluorescence-activated cell sorting for aptamer SELEX with cell mixtures

G Mayer, MSL Ahmed, A Dolf, E Endl, PA Knolle… - Nature protocols, 2010 - nature.com
Aptamers that target a specific cell subpopulation within composite mixtures represent
invaluable tools in biomedical research and in the development of cell-specific therapeutics …

[PDF][PDF] Enrichment of cell‐targeting and population‐specific aptamers by fluorescence‐activated cell sorting

MSL Raddatz, A Dolf, E Endl, P Knolle… - Angewandte …, 2008 - limes-institut-bonn.de
The reliable targeting of distinct cells and defined subpopulations of cells is an important
task in chemical biology and medicine. Therefore, sophisticated reagents are required that …

Single-molecule transition-state analysis of RNA folding

G Bokinsky, D Rueda, VK Misra… - Proceedings of the …, 2003 - National Acad Sciences
How RNA molecules fold into functional structures is a problem of great significance given
the expanding list of essential cellular RNA enzymes and the increasing number of …

Nucleic acid aptamers as tools and drugs: recent developments

M Rimmele - Chembiochem, 2003 - Wiley Online Library
Nucleic acid aptamers are molecules that bind to their ligands with high affinity and
specificity. Unlike other functional nucleic acids such as antisense oligonucleotides …

Biologisch aktive Moleküle mit “Lichtschalter”

G Mayer, A Heckel - Angewandte Chemie, 2006 - Wiley Online Library
Biologisch aktive Verbindungen, die auf Licht reagieren, bieten experimentelle
Möglichkeiten, die sonst nur sehr schwierig zu realisieren sind. Da Licht z. B. mit Lasern und …