Uptake transporters at the blood–brain barrier and their role in brain drug disposition

MM Parvez, A Sadighi, Y Ahn, SF Keller, JO Enoru - Pharmaceutics, 2023 - mdpi.com
Uptake drug transporters play a significant role in the pharmacokinetic of drugs within the
brain, facilitating their entry into the central nervous system (CNS). Understanding brain drug …

HIV antiretroviral medication neuropenetrance and neurocognitive outcomes in HIV+ adults: a review of the literature examining the central nervous system …

A Arentoft, K Troxell, K Alvarez, M Aghvinian… - Viruses, 2022 - mdpi.com
This literature review summarizes the existing research examining the CNS penetration
effectiveness (CPE) score and neurocognitive outcomes (ie, neuropsychological …

Hypromellose acetate succinate based amorphous solid dispersions via hot melt extrusion: Effect of drug physicochemical properties

S Sarabu, VR Kallakunta, S Bandari, A Batra, V Bi… - Carbohydrate …, 2020 - Elsevier
In this study, the impact of drug and hydroxypropyl methylcellulose acetate succinate
(HPMCAS) grades physicochemical properties on extrusion process, dissolution and …

Antiretroviral therapy intensification for neurocognitive impairment in human immunodeficiency virus

SL Letendre, H Chen, A McKhann, J Roa… - Clinical Infectious …, 2023 - academic.oup.com
Background Neurocognitive impairment (NCI) in people with HIV (PWH) on antiretroviral
therapy (ART) is common and may result from persistent HIV replication in the central …

Antiretroviral drug concentrations in brain tissue of adult decedents

M Ferrara, NN Bumpus, Q Ma, RJ Ellis… - Aids, 2020 - journals.lww.com
Objective: Determine concentrations of antiretroviral therapy (ART) drugs in the human
brain. Design: Cohort study of persons with HIV who consented to antemortem assessment …

Pharmacogenetics of the late-onset efavirenz neurotoxicity syndrome (LENS)

R van Rensburg, S Nightingale, N Brey… - Clinical Infectious …, 2022 - academic.oup.com
Background The late-onset efavirenz neurotoxicity syndrome (LENS) presents as ataxia
and/or encephalopathy with supratherapeutic efavirenz plasma concentrations (> 4 µg/mL) …

Clinical pharmacokinetics and pharmacodynamics of drugs in the central nervous system

N Srinivas, K Maffuid, ADM Kashuba - Clinical pharmacokinetics, 2018 - Springer
Despite contributing significantly to the burden of global disease, the translation of new
treatment strategies for diseases of the central nervous system (CNS) from animals to …

[HTML][HTML] Using mechanistic physiologically-based pharmacokinetic models to assess prenatal drug exposure: thalidomide versus efavirenz as case studies

SA Atoyebi, RKR Rajoli, E Adejuyigbe, A Owen… - European Journal of …, 2019 - Elsevier
Maternofoetal physiologically-based pharmacokinetic models integrating multi-
compartmental maternal and foetal units were developed using Simbiology® to estimate …

Efavirenz nanomicelles loaded vaginal film (EZ film) for preexposure prophylaxis (PrEP) of HIV

M Patki, R Vartak, J Jablonski, S Mediouni… - Colloids and Surfaces B …, 2020 - Elsevier
Preexposure prophylaxis (PrEP) using oral or vaginal microbicide is an emerging and
effective strategy to prevent HIV transmission. Vaginal film is becoming more acceptable and …

Improving the clinical relevance of a mouse pregnancy model of antiretroviral toxicity; a pharmacokinetic dosing-optimization study of current HIV antiretroviral …

S Kala, B Watson, JG Zhang, E Papp, MG Lenis… - Antiviral Research, 2018 - Elsevier
Animal models can be useful tools for the study of HIV antiretroviral (ARV) safety/toxicity in
pregnancy and the mechanisms that underlie ARV-associated adverse events. The utility …