Uptake transporters at the blood–brain barrier and their role in brain drug disposition
Uptake drug transporters play a significant role in the pharmacokinetic of drugs within the
brain, facilitating their entry into the central nervous system (CNS). Understanding brain drug …
brain, facilitating their entry into the central nervous system (CNS). Understanding brain drug …
HIV antiretroviral medication neuropenetrance and neurocognitive outcomes in HIV+ adults: a review of the literature examining the central nervous system …
A Arentoft, K Troxell, K Alvarez, M Aghvinian… - Viruses, 2022 - mdpi.com
This literature review summarizes the existing research examining the CNS penetration
effectiveness (CPE) score and neurocognitive outcomes (ie, neuropsychological …
effectiveness (CPE) score and neurocognitive outcomes (ie, neuropsychological …
Hypromellose acetate succinate based amorphous solid dispersions via hot melt extrusion: Effect of drug physicochemical properties
In this study, the impact of drug and hydroxypropyl methylcellulose acetate succinate
(HPMCAS) grades physicochemical properties on extrusion process, dissolution and …
(HPMCAS) grades physicochemical properties on extrusion process, dissolution and …
Antiretroviral therapy intensification for neurocognitive impairment in human immunodeficiency virus
SL Letendre, H Chen, A McKhann, J Roa… - Clinical Infectious …, 2023 - academic.oup.com
Background Neurocognitive impairment (NCI) in people with HIV (PWH) on antiretroviral
therapy (ART) is common and may result from persistent HIV replication in the central …
therapy (ART) is common and may result from persistent HIV replication in the central …
Antiretroviral drug concentrations in brain tissue of adult decedents
Objective: Determine concentrations of antiretroviral therapy (ART) drugs in the human
brain. Design: Cohort study of persons with HIV who consented to antemortem assessment …
brain. Design: Cohort study of persons with HIV who consented to antemortem assessment …
Pharmacogenetics of the late-onset efavirenz neurotoxicity syndrome (LENS)
Background The late-onset efavirenz neurotoxicity syndrome (LENS) presents as ataxia
and/or encephalopathy with supratherapeutic efavirenz plasma concentrations (> 4 µg/mL) …
and/or encephalopathy with supratherapeutic efavirenz plasma concentrations (> 4 µg/mL) …
Clinical pharmacokinetics and pharmacodynamics of drugs in the central nervous system
N Srinivas, K Maffuid, ADM Kashuba - Clinical pharmacokinetics, 2018 - Springer
Despite contributing significantly to the burden of global disease, the translation of new
treatment strategies for diseases of the central nervous system (CNS) from animals to …
treatment strategies for diseases of the central nervous system (CNS) from animals to …
[HTML][HTML] Using mechanistic physiologically-based pharmacokinetic models to assess prenatal drug exposure: thalidomide versus efavirenz as case studies
Maternofoetal physiologically-based pharmacokinetic models integrating multi-
compartmental maternal and foetal units were developed using Simbiology® to estimate …
compartmental maternal and foetal units were developed using Simbiology® to estimate …
Efavirenz nanomicelles loaded vaginal film (EZ film) for preexposure prophylaxis (PrEP) of HIV
Preexposure prophylaxis (PrEP) using oral or vaginal microbicide is an emerging and
effective strategy to prevent HIV transmission. Vaginal film is becoming more acceptable and …
effective strategy to prevent HIV transmission. Vaginal film is becoming more acceptable and …
Improving the clinical relevance of a mouse pregnancy model of antiretroviral toxicity; a pharmacokinetic dosing-optimization study of current HIV antiretroviral …
S Kala, B Watson, JG Zhang, E Papp, MG Lenis… - Antiviral Research, 2018 - Elsevier
Animal models can be useful tools for the study of HIV antiretroviral (ARV) safety/toxicity in
pregnancy and the mechanisms that underlie ARV-associated adverse events. The utility …
pregnancy and the mechanisms that underlie ARV-associated adverse events. The utility …