Chikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies
LA Silva, TS Dermody - The Journal of clinical investigation, 2017 - Am Soc Clin Investig
Chikungunya virus (CHIKV), a reemerging arbovirus, causes a crippling musculoskeletal
inflammatory disease in humans characterized by fever, polyarthralgia, myalgia, rash, and …
inflammatory disease in humans characterized by fever, polyarthralgia, myalgia, rash, and …
Distinct cellular tropism and immune responses to alphavirus infection
Alphaviruses are emerging and reemerging viruses that cause disease syndromes ranging
from incapacitating arthritis to potentially fatal encephalitis. While infection by arthritogenic …
from incapacitating arthritis to potentially fatal encephalitis. While infection by arthritogenic …
Chronic joint disease caused by persistent Chikungunya virus infection is controlled by the adaptive immune response
DW Hawman, KA Stoermer, SA Montgomery… - Journal of …, 2013 - Am Soc Microbiol
Chikungunya virus (CHIKV) is a reemerging mosquito-borne pathogen that causes
incapacitating disease in humans characterized by intense joint pain that can persist for …
incapacitating disease in humans characterized by intense joint pain that can persist for …
Multiple immune factors are involved in controlling acute and chronic chikungunya virus infection
YS Poo, PA Rudd, J Gardner, JAC Wilson… - PLoS neglected …, 2014 - journals.plos.org
The recent epidemic of the arthritogenic alphavirus, chikungunya virus (CHIKV) has
prompted a quest to understand the correlates of protection against virus and disease in …
prompted a quest to understand the correlates of protection against virus and disease in …
Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation
JD Cherry, JA Olschowka, MK O'Banion - Journal of neuroinflammation, 2015 - Springer
Background Neuroinflammation has long been considered a driver of Alzheimer's disease
progression. However, experiments developed to explore the interaction between …
progression. However, experiments developed to explore the interaction between …
Arginase 1 (Arg1) as an Up-Regulated Gene in COVID-19 Patients: A Promising Marker in COVID-19 Immunopathy
Background: The coronavirus disease 2019 (COVID-19) outbreak, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a global pandemic. It …
respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a global pandemic. It …
CCR2 deficiency promotes exacerbated chronic erosive neutrophil-dominated chikungunya virus arthritis
Chikungunya virus (CHIKV) is a member of a globally distributed group of arthritogenic
alphaviruses that cause weeks to months of debilitating polyarthritis/arthralgia, which is often …
alphaviruses that cause weeks to months of debilitating polyarthritis/arthralgia, which is often …
ISG15 governs mitochondrial function in macrophages following vaccinia virus infection
S Baldanta, M Fernandez-Escobar, R Acin-Perez… - PLoS …, 2017 - journals.plos.org
The interferon (IFN)-stimulated gene 15 (ISG15) encodes one of the most abundant proteins
induced by interferon, and its expression is associated with antiviral immunity. To identify …
induced by interferon, and its expression is associated with antiviral immunity. To identify …
Inflammatory monocytes mediate control of acute alphavirus infection in mice
KC Haist, KS Burrack, BJ Davenport… - PLoS …, 2017 - journals.plos.org
Chikungunya virus (CHIKV) and Ross River virus (RRV) are mosquito-transmitted
alphaviruses that cause debilitating acute and chronic musculoskeletal disease. Monocytes …
alphaviruses that cause debilitating acute and chronic musculoskeletal disease. Monocytes …
Immune-mediated protection and pathogenesis of chikungunya virus
JM Fox, MS Diamond - The Journal of Immunology, 2016 - journals.aai.org
Chikungunya virus (CHIKV) is a re-emerging alphavirus that causes debilitating acute and
chronic arthritis. Infection by CHIKV induces a robust immune response that is characterized …
chronic arthritis. Infection by CHIKV induces a robust immune response that is characterized …