Chikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies

LA Silva, TS Dermody - The Journal of clinical investigation, 2017 - Am Soc Clin Investig
Chikungunya virus (CHIKV), a reemerging arbovirus, causes a crippling musculoskeletal
inflammatory disease in humans characterized by fever, polyarthralgia, myalgia, rash, and …

Distinct cellular tropism and immune responses to alphavirus infection

NM Kafai, MS Diamond, JM Fox - Annual review of immunology, 2022 - annualreviews.org
Alphaviruses are emerging and reemerging viruses that cause disease syndromes ranging
from incapacitating arthritis to potentially fatal encephalitis. While infection by arthritogenic …

Chronic joint disease caused by persistent Chikungunya virus infection is controlled by the adaptive immune response

DW Hawman, KA Stoermer, SA Montgomery… - Journal of …, 2013 - Am Soc Microbiol
Chikungunya virus (CHIKV) is a reemerging mosquito-borne pathogen that causes
incapacitating disease in humans characterized by intense joint pain that can persist for …

Multiple immune factors are involved in controlling acute and chronic chikungunya virus infection

YS Poo, PA Rudd, J Gardner, JAC Wilson… - PLoS neglected …, 2014 - journals.plos.org
The recent epidemic of the arthritogenic alphavirus, chikungunya virus (CHIKV) has
prompted a quest to understand the correlates of protection against virus and disease in …

Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation

JD Cherry, JA Olschowka, MK O'Banion - Journal of neuroinflammation, 2015 - Springer
Background Neuroinflammation has long been considered a driver of Alzheimer's disease
progression. However, experiments developed to explore the interaction between …

Arginase 1 (Arg1) as an Up-Regulated Gene in COVID-19 Patients: A Promising Marker in COVID-19 Immunopathy

A Derakhshani, N Hemmat, Z Asadzadeh… - Journal of clinical …, 2021 - mdpi.com
Background: The coronavirus disease 2019 (COVID-19) outbreak, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a global pandemic. It …

CCR2 deficiency promotes exacerbated chronic erosive neutrophil-dominated chikungunya virus arthritis

YS Poo, H Nakaya, J Gardner, T Larcher… - Journal of …, 2014 - Am Soc Microbiol
Chikungunya virus (CHIKV) is a member of a globally distributed group of arthritogenic
alphaviruses that cause weeks to months of debilitating polyarthritis/arthralgia, which is often …

ISG15 governs mitochondrial function in macrophages following vaccinia virus infection

S Baldanta, M Fernandez-Escobar, R Acin-Perez… - PLoS …, 2017 - journals.plos.org
The interferon (IFN)-stimulated gene 15 (ISG15) encodes one of the most abundant proteins
induced by interferon, and its expression is associated with antiviral immunity. To identify …

Inflammatory monocytes mediate control of acute alphavirus infection in mice

KC Haist, KS Burrack, BJ Davenport… - PLoS …, 2017 - journals.plos.org
Chikungunya virus (CHIKV) and Ross River virus (RRV) are mosquito-transmitted
alphaviruses that cause debilitating acute and chronic musculoskeletal disease. Monocytes …

Immune-mediated protection and pathogenesis of chikungunya virus

JM Fox, MS Diamond - The Journal of Immunology, 2016 - journals.aai.org
Chikungunya virus (CHIKV) is a re-emerging alphavirus that causes debilitating acute and
chronic arthritis. Infection by CHIKV induces a robust immune response that is characterized …