Mediators of chronic obstructive pulmonary disease
PJ Barnes - Pharmacological reviews, 2004 - ASPET
Chronic obstructive pulmonary disease (COPD) is a major and increasing global health
problem that is now a leading cause of death. COPD is associated with a chronic …
problem that is now a leading cause of death. COPD is associated with a chronic …
Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease
T Yoshida, RM Tuder - Physiological reviews, 2007 - journals.physiology.org
Chronic obstructive pulmonary diseases (COPD), comprised of pulmonary emphysema,
chronic bronchitis, and structural and inflammatory changes of small airways, is a leading …
chronic bronchitis, and structural and inflammatory changes of small airways, is a leading …
Muscarinic receptor signaling in the pathophysiology of asthma and COPD
Anticholinergics are widely used for the treatment of COPD, and to a lesser extent for
asthma. Primarily used as bronchodilators, they reverse the action of vagally derived …
asthma. Primarily used as bronchodilators, they reverse the action of vagally derived …
Cytokine inhibition in the treatment of COPD
G Caramori, IM Adcock, A Di Stefano… - International journal of …, 2014 - Taylor & Francis
Cytokines play an important part in many pathobiological processes of chronic obstructive
pulmonary disease (COPD), including the chronic inflammatory process, emphysema, and …
pulmonary disease (COPD), including the chronic inflammatory process, emphysema, and …
Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells
L Marek, KE Ware, A Fritzsche, P Hercule… - Molecular …, 2009 - ASPET
Despite widespread expression of epidermal growth factor (EGF) receptors (EGFRs) and
EGF family ligands in non-small-cell lung cancer (NSCLC), EGFR-specific tyrosine kinase …
EGF family ligands in non-small-cell lung cancer (NSCLC), EGFR-specific tyrosine kinase …
Senescence-associated secretory phenotype and its possible role in chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is a major disease of the lungs. It primarily
occurs after a prolonged period of cigarette smoking. Chronic inflammation of airways and …
occurs after a prolonged period of cigarette smoking. Chronic inflammation of airways and …
Prospects for new drugs for chronic obstructive pulmonary disease
PJ Barnes, TT Hansel - The Lancet, 2004 - thelancet.com
No currently available treatments have been shown to slow the progression of chronic
obstructive pulmonary disease (COPD) or suppress the inflammation in small airways and …
obstructive pulmonary disease (COPD) or suppress the inflammation in small airways and …
Pathogenesis of chronic obstructive pulmonary disease
W MacNee - Clinics in chest medicine, 2007 - Elsevier
The pathogenesis of chronic obstructive pulmonary disease (COPD) encompasses a
number of injurious processes, including an abnormal inflammatory response in the lungs to …
number of injurious processes, including an abnormal inflammatory response in the lungs to …
Enhanced bronchial expression of vascular endothelial growth factor and receptors (Flk-1 and Flt-1) in patients with chronic obstructive pulmonary disease
AR Kranenburg, WI De Boer, VKT Alagappan, PJ Sterk… - Thorax, 2005 - thorax.bmj.com
Background: Ongoing inflammatory processes resulting in airway and vascular remodelling
characterise chronic obstructive pulmonary disease (COPD). Vascular endothelial growth …
characterise chronic obstructive pulmonary disease (COPD). Vascular endothelial growth …
Fibroblast growth factor‐1 attenuates TGF‐β1‐induced lung fibrosis
C Shimbori, PS Bellaye, J Xia, J Gauldie… - The Journal of …, 2016 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is characterized by progressive fibroblast and
myofibroblast proliferation, and extensive deposition of extracellular matrix (ECM). Fibroblast …
myofibroblast proliferation, and extensive deposition of extracellular matrix (ECM). Fibroblast …