Transthyretin amyloid cardiomyopathy (ATTR-CM) results in a restrictive cardiomyopathy
caused by extracellular deposition of transthyretin, normally involved in the transportation of …

Cardiomyopathy is a manifestation of transthyretin amyloidosis (ATTR), which is an
underrecognized systemic disease whereby the transthyretin protein misfolds to form fibrils …

Background: Patients with cardiac amyloidosis often have carpal tunnel syndrome that
precedes cardiac manifestations by several years. However, the prevalence of cardiac …

Transthyretin cardiac amyloidosis (ATTR-CA) is an increasingly recognized cause of heart
failure (HF) and mortality worldwide. Advances in non-invasive diagnosis, coupled with the …

[CQ1] What is the role of 99 mTc-PYP scintigraphy (bone scintigraphy) in clinical practice for
CA?∙∙∙∙∙∙ 1655 [CQ2] The role of endomyocardial biopsy. Which site is appropriate for biopsy …

Integrating genetic information with metabolomics has provided new insights into genes
affecting human metabolism. However, gene-metabolite integration has been primarily …

Background: Plasma proteins are critical mediators of cardiovascular processes and are the
targets of many drugs. Previous efforts to characterize the genetic architecture of the plasma …

Over the last year, 5 national or international scientific societies have issued documents
regarding cardiac amyloidosis (CA) to highlight the emerging clinical science, raise …

Abstract Background Cardiac Amyloidosis (CA) pertains to the cardiac involvement of a
group of diseases, in which misfolded proteins deposit in tissues and cause progressive …

Amyloidoses represent a group of diseases characterized by the pathological accumulation
in the extracellular area of insoluble misfolded protein material called “amyloid”. The …