Progressive multifocal leukoencephalopathy (PML) is a devastating CNS infection caused
by JC virus (JCV), a polyomavirus that commonly establishes persistent, asymptomatic …

The American Society for Apheresis (ASFA) Journal of Clinical Apheresis (JCA) Special
Issue Writing Committee is charged with reviewing, updating, and categorizing indications …

ABSTRACT The American Society for Apheresis (ASFA) Journal of Clinical Apheresis (JCA)
Special Issue Writing Committee is charged with reviewing, updating and categorizing …

The human immunodeficiency virus-1 (HIV-1) enters target cells by binding its envelope
glycoprotein gp120 to the CD4 receptor and/or coreceptors such as CC chemokine receptor …

Progressive multifocal leukoencephalopathy (PML) is a rare but debilitating and frequently
fatal viral disease of the central nervous system, primarily affecting individuals with …

Access to antiretroviral therapy (ART) is improving worldwide. Immune reconstitution
inflammatory syndrome (IRIS) is a common complication of ART initiation. In this review, we …

Almost every disorder of the CNS is said to have an inflammatory component, but the
precise nature of inflammation in the CNS is often imprecisely defined, and the role of CNS …

Natalizumab is a monoclonal antibody that acts as an α4 integrin antagonist to prevent
leukocyte trafficking into the central nervous system. It is US Food and Drug Administration …

Cases of PML should be evaluated according to predisposing factors, as these subgroups
differ by incidence rate, clinical course, and prognosis. The three most significant groups at …

Chemokine receptors have been implicated in a wide range of CNS inflammatory diseases
and have important roles in the recruitment and positioning of immune cells within tissues …