The cornea is the most densely innervated and sensitive tissue in the body. The cornea is
exclusively innervated by C-and A-delta fibers, including mechano-nociceptors that are …

As the cornea is densely innervated, its nerves are integral not only to its structure but also to
its pathophysiology. Corneal integrity depends on a protective tear film that is maintained by …

The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans,
activated by low temperatures (> 10,< 28° C), but also a polymodal ion channel, stimulated …

Dry eye disease (DED) is a multifactorial disorder in which the eyes respond to minor stimuli
with abnormal sensations, such as dryness, blurring, foreign body sensation, discomfort …

Persistent ocular pain caused by corneal inflammation and/or nerve injury is accompanied
by significant alterations along the pain axis. Both primary sensory neurons in the trigeminal …

Patients with corneal and conjunctival disorders report an array of ocular surface symptoms
including stinging, foreign body sensation, and itching. The intensity and perceptual quality …

Abstract The pathophysiology of Dry Eye Disease (DED) is complex, and therapy may be a
challenge. Tear film instability, tear film hyperosmolarity, ocular surface damage and ocular …

Purpose Corneal nerves comprise the densest sensory network in the body. Dysfunction of
the corneal cold sensitive neurons (CSN) is implicated in ophthalmic disorders, including …

Proper sight is not possible without a smooth, transparent cornea, which is highly exposed to
environmental threats. The abundant corneal nerves are interspersed with epithelial cells in …

Dry eye disease (DED) is commonly associated with ocular surface inflammation and pain.
In this study, we evaluated the effectiveness of repeated instillations of transient receptor …