The plants of the genus Phyllanthus (Euphorbiaceae) are widely distributed in most tropical
and subtropical countries, and have long been used in folk medicine to treat kidney and …

Pain is an unpleasant sensation associated with a wide range of injuries and diseases, and
affects approximately 20% of adults in the world. The discovery of new and more effective …

ETHNOPHARMACOLOGICAL RELEVANCE: Salvia officinalis L. has been used as a
traditional herbal medicine for gastric disturbances and inflammatory processes. This study …

Cytokines and reactive oxygen species are inflammatory mediators that lead to increased
sensitivity to painful stimuli, and their inhibition represents a therapeutic approach in …

The specific functions of sensory systems depend on the tissue-specific expression of genes
that code for molecular sensor proteins that are necessary for stimulus detection and …

The antinociceptive action of quercetin, a common bioactive flavonoid present in many
medicinal plants, was assessed in different models of chemical and thermal nociception in …

A novel series of feruloyl-donepezil hybrid compounds were designed, synthesized and
evaluated as multitarget drug candidates for the treatment of Alzheimer's Disease (AD). In …

The objective of this study was to evaluate the anti-inflammatory and analgesic activities of
the hydro-alcoholic extract of the pods of Astragalus hamosus (HAAH), a plant used in …

Dipyrone injected intraperitoneally (ip) or subplantarly into the mouse paw caused dose-
related antinociception against the early and the late phases of formalin-induced licking …

This study investigates the antinociception caused by intradermal (id) or
intracerebroventricular (icv) injection of the capsaicin receptor antagonist capsazepine …