Clustered imprinted genes are regulated by differentially methylated imprinting control
regions (ICRs) that affect gene activity and repression in cis over a large region. Although a …

Genomic imprinting refers to an epigenetic marking of genes that results in monoallelic
expression. This parent-of-origin dependent phenomenon is a notable exception to the laws …

Background The paternal duplication of mouse distal chromosome 12 leads to late
embryonal/neonatal lethality and growth promotion, whereas maternal duplication leads to …

Sex hormones such as estrogen and testosterone are essential for sexually dimorphic
behaviors in vertebrates. However, the hormone-activated molecular mechanisms that …

Genomic imprinting in gametogenesis marks a subset of mammalian genes for parent‐of‐
origin‐dependent monoallelic expression in the offspring. Embryological and classical …

A novel paternally expressed imprinted gene, PEG10 (Paternally Expressed 10), was
identified on human chromosome 7q21. PEG10 is located near the SGCE (Sarcoglycan ϵ) …

Heterozygous NRXN1 deletions constitute the most prevalent currently known single-gene
mutation associated with schizophrenia, and additionally predispose to multiple other …

Embryos generated with the use of assisted reproductive technologies (ART) can develop
overgrowth syndromes. In ruminants, the condition is referred to as large offspring syndrome …

Genomic imprinting is widespread in eutherian mammals. Marsupial mammals also have
genomic imprinting, but in fewer loci. It has long been thought that genomic imprinting is …

Imprinted genes display differential allelic expression in a manner that depends on the sex
of the transmitting parent. The degree of imprinting is often tissue-specific and/or …