Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …

A renewed interest in the characteristics and neural basis of corneal and conjunctival
sensations is developing in recent years due to the high incidence of discomfort and altered …

Eye pain is an unpleasant sensory and emotional experience including sensory-
discriminative, emotional, cognitive, and behavioral components and supported by distinct …

Basal tearing is crucial to maintaining ocular surface wetness. Corneal cold thermoreceptors
sense small oscillations in ambient temperature and change their discharge accordingly …

The cornea is the most densely innervated and sensitive tissue in the body. The cornea is
exclusively innervated by C-and A-delta fibers, including mechano-nociceptors that are …

As the biological alarm of impending or actual tissue damage, pain is essential for our
survival. However, when it is initiated and/or sustained by dysfunctional elements in the …

purpose. Tear film instability and tear hyperosmolarity are considered core mechanisms in
the development of dry eye. The authors hypothesize that evaporation and instability …

purpose. An alteration in corneal innervation has been described in dry eye associated with
diabetes mellitus, contact lens use, and LASIK. The purpose of this study was to evaluate …

As the cornea is densely innervated, its nerves are integral not only to its structure but also to
its pathophysiology. Corneal integrity depends on a protective tear film that is maintained by …

purpose. To explore changes in corneal sensitivity that develop in patients with dry eye and
the relationship between sensibility and severity of the dry eye disease. methods …