Non-invasive measurements of ictal and interictal epileptiform activity using optically pumped magnetometers

A Hillebrand, N Holmes, N Sijsma, GC O'Neill… - Scientific reports, 2023 - nature.com
Magneto-and electroencephalography (MEG/EEG) are important techniques for the
diagnosis and pre-surgical evaluation of epilepsy. Yet, in current cryogen-based MEG …

[HTML][HTML] Big data in stroke: how to use big data to make the next management decision

Y Liu, Y Luo, AM Naidech - Neurotherapeutics, 2023 - Elsevier
The last decade has seen significant advances in the accumulation of medical data, the
computational techniques to analyze that data, and corresponding improvements in …

High‐frequency oscillations (250–500 Hz) in animal models of Alzheimer's disease and two animal models of epilepsy

CP Lisgaras, HE Scharfman - Epilepsia, 2023 - Wiley Online Library
Objective To test the hypothesis that high‐frequency oscillations (HFOs) between 250 and
500 Hz occur in mouse models of Alzheimer's disease (AD) and thus are not unique to …

Recent advances in epilepsy surgery

M Medina-Pizarro, DD Spencer… - Current Opinion in …, 2023 - journals.lww.com
Epilepsy surgery is still underutilized worldwide. Every patient who continues with seizures
despite adequate trials of two well selected and tolerated antiseizure medications should be …

[HTML][HTML] Capturing the power of seizures: an empirical mode decomposition analysis of epileptic activity in the mouse hippocampus

L Molnár, I Ferando, B Liu, P Mokhtar… - Frontiers in Molecular …, 2023 - frontiersin.org
Introduction: Various methods have been used to determine the frequency components of
seizures in scalp electroencephalography (EEG) and in intracortical recordings. Most of …

Subclinical epileptiform activity and sleep disturbances in Alzheimer's disease

A Devulder, J Macea, A Kalkanis… - Brain and …, 2023 - Wiley Online Library
Introduction Subclinical epileptiform activity (SEA) and sleep disturbances are frequent in
Alzheimer's disease (AD). Both have an important relation to cognition and potential …

Etiology and clinical significance of network hyperexcitability in alzheimer's disease: Unanswered questions and next steps

N Samudra, K Ranasinghe, H Kirsch… - Journal of …, 2023 - content.iospress.com
Cortical network hyperexcitability related to synaptic dysfunction in Alzheimer's disease (AD)
is a potential target for therapeutic intervention. In recent years, there has been increased …

Subclinical epileptiform activity in the Alzheimer continuum: association with disease, cognition and detection method

A Nous, L Seynaeve, O Feys, V Wens… - Alzheimer's research & …, 2024 - Springer
Background Epileptic seizures are an established comorbidity of Alzheimer's disease (AD).
Subclinical epileptiform activity (SEA) as detected by 24-h electroencephalography (EEG) or …

Epilepsy and epileptiform activity in late-onset Alzheimer disease: clinical and pathophysiological advances, gaps and conundrums

A Kamondi, M Grigg-Damberger, W Löscher… - Nature Reviews …, 2024 - nature.com
A growing body of evidence has demonstrated a link between Alzheimer disease (AD) and
epilepsy. Late-onset epilepsy and epileptiform activity can precede cognitive deterioration in …

Altered sleep microarchitecture and cognitive impairment in patients with temporal lobe epilepsy

AC Bender, A Jaleel, KR Pellerin, S Moguilner… - Neurology, 2023 - AAN Enterprises
Background and Objectives To investigate the spatiotemporal characteristics of sleep
waveforms in temporal lobe epilepsy (TLE) and examine their association with cognition …