The pathophysiology of atopic dermatitis is complex and multifactorial, involving elements of
barrier dysfunction, alterations in cell mediated immune responses, IgE mediated …

Type-2-cell-mediated immunity, rich in eosinophils, basophils, mast cells, CD4+ T helper 2
(Th2) cells, and type 2 innate lymphoid cells (ILC2s), protects the host from helminth …

Atopic dermatitis often precedes the development of other atopic diseases. The atopic march
describes this temporal relationship in the natural history of atopic diseases. Although the …

The skin is the largest organ of the mammalian body. The outermost layer of mammalian
skin, the stratum corneum (SC) of the epidermis, consists of piles of dead corneocytes that …

Background Susceptibility to asthma is influenced by genes and environment; implicated
genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful …

Atopic dermatitis (AD), a chronic relapsing inflammatory skin disease, is increasing in
prevalence around the world. Intensive research is ongoing to understand the mechanisms …

Atopic dermatitis (AD) is the most common inflammatory skin disease in the industrialized
world and has multiple causes. Over the past decade, data from both experimental models …

The skin forms an effective barrier between the organism and the environment preventing
invasion of pathogens and fending off chemical and physical assaults, as well as the …

The primary function of the epidermis is to produce the protective, semi-permeable stratum
corneum that permits terrestrial life. The barrier function of the stratum corneum is provided …

Classic atopic dermatitis is complicated by asthma, allergic rhinitis, and food allergies,
cumulatively referred to as atopic diseases. Recent discoveries of mutations in the filaggrin …