Recent progress in whole-genome mapping and imaging technologies has enabled the
characterization of the spatial organization and folding of the genome in the nucleus. In …

Cytosine DNA methylation is essential in brain development and is implicated in various
neurological disorders. Understanding DNA methylation diversity across the entire brain in a …

Olfactory receptor (OR) choice provides an extreme example of allelic competition for
transcriptional dominance, where every olfactory neuron stably transcribes one of …

Dynamically organized chromatin complexes often involve multiplex chromatin interactions
and sometimes chromatin-associated RNA,–. Chromatin complex compositions change …

Embryonic neurodevelopment, particularly neural progenitor differentiation into post-mitotic
neurons, has been extensively studied. While the number and composition of post-mitotic …

Abstract 3D organization of the genome plays a critical role in regulating gene expression.
However, it remains unclear how chromatin organization differs among different cell types in …

The contribution of three-dimensional genome organization to physiological ageing is not
well known. Here we show that large-scale chromatin reorganization distinguishes young …

Two different models have been proposed to explain how the endpoints of chromatin looped
domains (“TADs”) in eukaryotic chromosomes are determined. In the first, a cohesin complex …

Late-onset Alzheimer's disease (LOAD) is typically sporadic, correlated only to advanced
age, and has no clear genetic risk factors. The sporadic nature of LOAD presents a …

Cell-specific transcriptomic and epigenomic programming during human brain development
and differentiation are associated with dynamic changes in chromosomal conformations …