Cytosine DNA methylation is essential in brain development and is implicated in various
neurological disorders. Understanding DNA methylation diversity across the entire brain in a …

Dynamically organized chromatin complexes often involve multiplex chromatin interactions
and sometimes chromatin-associated RNA,–. Chromatin complex compositions change …

Embryonic neurodevelopment, particularly neural progenitor differentiation into post-mitotic
neurons, has been extensively studied. While the number and composition of post-mitotic …

The contribution of three-dimensional genome organization to physiological ageing is not
well known. Here we show that large-scale chromatin reorganization distinguishes young …

Two different models have been proposed to explain how the endpoints of chromatin looped
domains (“TADs”) in eukaryotic chromosomes are determined. In the first, a cohesin complex …

3D organization of the genome plays a critical role in regulating gene expression. However,
it remains unclear how chromatin organization differs among different cell types in the brain …

Cell-specific transcriptomic and epigenomic programming during human brain development
and differentiation are associated with dynamic changes in chromosomal conformations …

The dynamically organized chromatin complexes often involve multiplex chromatin
interactions 16 and sometimes chromatin-associated RNA. Here, we introduce the Multi …

Late-onset Alzheimer's disease (LOAD) is typically sporadic, correlated only to advanced
age, and has no clear genetic risk factors. The sporadic nature of LOAD presents a …

Exploring the genomic basis of transcriptional programs has been a longstanding research
focus. Here, we report a high-throughput single-cell tri-omic method to capture chromatin …