The Epidemiology and Pathogenesis and Treatment of Pseudomonas aeruginosa Infections: An Update
D Reynolds, M Kollef - Drugs, 2021 - Springer
Pseudomonas aeruginosa is a Gram-negative bacterial pathogen that is a common cause of
nosocomial infections, particularly pneumonia, infection in immunocompromised hosts, and …
nosocomial infections, particularly pneumonia, infection in immunocompromised hosts, and …
Pseudomonas aeruginosa: Infections, Animal Modeling, and Therapeutics
SJ Wood, TM Kuzel, SH Shafikhani - Cells, 2023 - mdpi.com
Pseudomonas aeruginosa is an important Gram-negative opportunistic pathogen which
causes many severe acute and chronic infections with high morbidity, and mortality rates as …
causes many severe acute and chronic infections with high morbidity, and mortality rates as …
Cystic fibrosis and Pseudomonas aeruginosa: the host-microbe interface
In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …
Functional effects of the microbiota in chronic respiratory disease
The composition of the lung microbiome is increasingly well characterised, with changes in
microbial diversity or abundance observed in association with several chronic respiratory …
microbial diversity or abundance observed in association with several chronic respiratory …
Cystic fibrosis genetics: from molecular understanding to clinical application
GR Cutting - Nature Reviews Genetics, 2015 - nature.com
The availability of the human genome sequence and tools for interrogating individual
genomes provide an unprecedented opportunity to apply genetics to medicine. Mendelian …
genomes provide an unprecedented opportunity to apply genetics to medicine. Mendelian …
Clinical mechanism of the cystic fibrosis transmembrane conductance regulator potentiator ivacaftor in G551D-mediated cystic fibrosis
SM Rowe, SL Heltshe, T Gonska… - American journal of …, 2014 - atsjournals.org
Rationale: Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR)
potentiator recently approved for patients with CF age 6 and older with the G551D mutation …
potentiator recently approved for patients with CF age 6 and older with the G551D mutation …
Secondary effects of antibiotics on microbial biofilms
Biofilms are assemblages of microorganisms attached to each other, or to a surface, and
encased in a protective, self-produced matrix. Such associations are now recognized as the …
encased in a protective, self-produced matrix. Such associations are now recognized as the …
Impact of Pseudomonas aeruginosa Infection on Patients with Chronic Inflammatory Airway Diseases
M Garcia-Clemente, D de la Rosa, L Máiz… - Journal of clinical …, 2020 - mdpi.com
Pseudomonas aeruginosa (P. aeruginosa) is a ubiquitous and opportunistic microorganism
and is considered one of the most significant pathogens that produce chronic colonization …
and is considered one of the most significant pathogens that produce chronic colonization …
Clinical significance of microbial infection and adaptation in cystic fibrosis
AR Hauser, M Jain, M Bar-Meir… - Clinical microbiology …, 2011 - Am Soc Microbiol
SUMMARY A select group of microorganisms inhabit the airways of individuals with cystic
fibrosis. Once established within the pulmonary environment in these patients, many of …
fibrosis. Once established within the pulmonary environment in these patients, many of …
The adult cystic fibrosis airway microbiota is stable over time and infection type, and highly resilient to antibiotic treatment of exacerbations
Cystic fibrosis (CF) is characterized by defective mucociliary clearance and chronic airway
infection by a complex microbiota. Infection, persistent inflammation and periodic episodes …
infection by a complex microbiota. Infection, persistent inflammation and periodic episodes …