Design of Coiled-coil Protein Nanostructures for Therapeutics and Drug Delivery

D Britton, JW Sun, PD Renfrew… - Annual Review of …, 2024 - annualreviews.org
Coiled-coil protein motifs have become widely employed in the design of biomaterials.
Some of these designs have been studied for use in drug delivery due to the unique ability …

An overview of enhancing the performance of medical implants with nanocomposites

M Ramezani, ZM Ripin - Journal of Composites Science, 2023 - mdpi.com
Medical implants are essential tools for treating chronic illnesses, restoring physical function,
and improving the quality of life for millions of patients worldwide. However, implant failures …

Engineered Proteins and Materials Utilizing Residue-Specific Noncanonical Amino Acid Incorporation

T Majekodunmi, D Britton, JK Montclare - Chemical reviews, 2024 - ACS Publications
The incorporation of noncanonical amino acids into proteins and protein-based materials
has significantly expanded the repertoire of available protein structures and chemistries …

Coiled-Coil Protein Hydrogels Engineered with Minimized Fiber Diameters for Sustained Release of Doxorubicin in Triple-Negative Breast Cancer

D Britton, J Legocki, D Paul, O Katsara… - ACS Biomaterials …, 2024 - ACS Publications
Triple-negative breast cancer (TNBC) lacks expressed protein targets, making therapy
development challenging. Hydrogels offer a promising new route in this regard by improving …

Supramolecular Assembly and Small-Molecule Binding by Protein-Engineered Coiled-Coil Fibers

D Britton, J Monkovic, S Jia, C Liu… - …, 2022 - ACS Publications
The ability to engineer a solvent-exposed surface of self-assembling coiled coils allows one
to achieve a higher-order hierarchical assembly such as nano-or microfibers. Currently …

Protein-Engineered Fibers For Drug Encapsulation Traceable via 19F Magnetic Resonance

D Britton, J Legocki, O Aristizabal… - ACS Applied Nano …, 2023 - ACS Publications
Theranostic materials research is experiencing rapid growth driven by the interest in
integrating both therapeutic and diagnostic modalities. These materials offer the unique …

Dual coiled-coil protein domain mimic and drug delivery vehicle for SARS-CoV-2

D Britton, C Liu, S Jia, D Paul, J Legocki, Y Xiao… - Biochemical …, 2024 - Elsevier
SARS-CoV-2 has emerged as a strong target for the development of protein domain mimics
(PDMs) as it relies on the helical protein-protein interaction (PPI) between the N-terminal α …

Recombinant Fibrous Protein Gels as Rheological Modifiers in Skin Ointments

D Britton, J Sun, HA Faizi, L Yin, W Gao… - ACS Applied Polymer …, 2024 - ACS Publications
Rheological modifiers are an important component in the development of skin cream (SC)
chassis for personal skin care products (PSCPs). The viscous behavior of a PSCP is critical …

Strategies and Applications for Supramolecular Protein Self‐Assembly

Y Li, R Tian, Y Zou, T Wang, J Liu - Chemistry–A European Journal - Wiley Online Library
Supramolecular chemistry achieves higher‐order molecular self‐assembly through non‐
covalent interactions. Utilizing supramolecular methods to explore the polymorphism of …