Cellular host factors for SARS-CoV-2 infection
Abstract The coronavirus disease 2019 (COVID-19) pandemic has claimed millions of lives
and caused a global economic crisis. No effective antiviral drugs are currently available to …
and caused a global economic crisis. No effective antiviral drugs are currently available to …
[HTML][HTML] Angiotensin-converting enzyme 2—at the heart of the COVID-19 pandemic
ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the
COVID-19 pandemic, it has become one of the most therapeutically targeted human …
COVID-19 pandemic, it has become one of the most therapeutically targeted human …
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
B Meng, A Abdullahi, IATM Ferreira, N Goonawardane… - Nature, 2022 - nature.com
Abstract The SARS-CoV-2 Omicron BA. 1 variant emerged in 2021 and has multiple
mutations in its spike protein. Here we show that the spike protein of Omicron has a higher …
mutations in its spike protein. Here we show that the spike protein of Omicron has a higher …
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-
converting enzyme 2 (ACE2), could represent a new chemoprophylactic approach for …
converting enzyme 2 (ACE2), could represent a new chemoprophylactic approach for …
SARS-CoV-2 B. 1.617. 2 Delta variant replication and immune evasion
Abstract The B. 1.617. 2 (Delta) variant of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) was first identified in the state of Maharashtra in late 2020 and spread …
(SARS-CoV-2) was first identified in the state of Maharashtra in late 2020 and spread …
[HTML][HTML] Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B. 1.1. 7
We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70
in multiple independent lineages, often occurring after acquisition of receptor binding motif …
in multiple independent lineages, often occurring after acquisition of receptor binding motif …
TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells
J Koch, ZM Uckeley, P Doldan, M Stanifer… - The EMBO …, 2021 - embopress.org
SARS‐CoV‐2 is a newly emerged coronavirus that caused the global COVID‐19 outbreak in
early 2020. COVID‐19 is primarily associated with lung injury, but many other clinical …
early 2020. COVID‐19 is primarily associated with lung injury, but many other clinical …
[HTML][HTML] SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF barrier in human brain organoids
Summary Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) virus, leads to respiratory symptoms that can be …
syndrome coronavirus 2 (SARS-CoV-2) virus, leads to respiratory symptoms that can be …
The hyper-transmissible SARS-CoV-2 Omicron variant exhibits significant antigenic change, vaccine escape and a switch in cell entry mechanism
Vaccination-based exposure to spike protein derived from early SARS-CoV-2 sequences is
the key public health strategy against COVID-19. Successive waves of SARS-CoV-2 …
the key public health strategy against COVID-19. Successive waves of SARS-CoV-2 …
[HTML][HTML] D614G mutation alters SARS-CoV-2 spike conformation and enhances protease cleavage at the S1/S2 junction
The severe acute respiratory coronavirus 2 (SARS-CoV-2) spike (S) protein is the target of
vaccine design efforts to end the coronavirus disease 2019 (COVID-19) pandemic. Despite …
vaccine design efforts to end the coronavirus disease 2019 (COVID-19) pandemic. Despite …