Toll‐like receptors (TLRs) are germline‐encoded receptors that are central to innate and
adaptive immune responses. Owing to their vital role in inflammation, TLRs are rational …

Abstract mRNA formulated with lipid nanoparticles is a transformative technology that has
enabled the rapid development and administration of billions of coronavirus disease 2019 …

Toll-like receptors (TLRs) serve as the body's first line of defense, recognizing both
pathogen-expressed molecules and host-derived molecules released from damaged or …

The majority of therapeutics target membrane proteins, accessible on the surface of cells, to
alter cellular signaling. Cells use membrane proteins to transduce signals into cells …

Conspectus Toll-like receptors (TLRs) are the “gatekeepers” of the immune system in
humans and other animals to protect the host from invading bacteria, viruses, and other …

Protein–RNA interactions have crucial roles in various cellular activities, which, when
dysregulated, can lead to a range of human diseases. The identification of small molecules …

Abstract Toll/IL-1R domain-containing adaptor-inducing IFN-β (TRIF)-dependent signaling is
required for TLR-mediated production of type-I IFN and several other proinflammatory …

Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) rapidly infects
humans and animals which make coronavirus disease 2019 (COVID-19) a grievous …

In the past few years, new developments have been reported on the role of Toll-like
receptors (TLRs) in chronic inflammation in rheumatic diseases. The inhibitory function of …

Toll-like receptors (TLRs) are key components of the innate immune system and serve as a
crucial link between innate and acquired immunity. In addition to immune function, TLRs are …