WNKs are serine/threonine kinases that comprise a unique branch of the kinome. They are
so-named owing to the unusual placement of an essential catalytic lysine. WNKs have now …

The elucidation of genes implicated in Mendelian forms of hypertension demonstrates rare
variants with substantial effects are responsible, and often these genes lie within pathways …

The increasing burden of obesity worldwide and its effect on cardiovascular disease (CVD)
risk is an opportunity for evaluation of preventive approaches. Both obesity and CVD have a …

This review provides a translational and unifying summary of metabolic syndrome genetics
and highlights evidence that genetic studies are starting to unravel and untangle origins of …

The renal outer medullary potassium channel (ROMK or Kir1. 1) is a putative drug target for
a novel class of diuretics that could be used for the treatment of hypertension and …

WNK1-a serine/threonine kinase involved in electrolyte homeostasis and blood pressure
(BP) control-is an excellent candidate gene for essential hypertension (EH). We and others …

ROMK, the renal outer medullary potassium channel, is involved in potassium recycling at
the thick ascending loop of Henle and potassium secretion at the cortical collecting duct in …

It has been well characterized that flavonoids possess pronounced anticancer potentials
including anti-angiogenesis, anti-metastasis, and pro-apoptosis. Herein, we report, for the …

Recently, a genome-wide association study reported an association between two single
nucleotide polymorphisms (SNPs) rs11833579 and rs12425791 near NINJ2 gene and …

The discovery of the renal WNK kinase pathway is offering new insights into sodium,
potassium and blood pressure regulation in the distal nephron. It has also largely explained …