The retromer complex has a well-established role in endosomal protein sorting, being
necessary for maintaining the dynamic localisation of hundreds of membrane proteins that …

Nano-based drug delivery systems are increasingly used for diagnosis, prevention and
treatment of several diseases, thanks to several beneficial properties, including the ability to …

Biogenesis of viral replication organelles (VROs) is critical for replication of positive-strand
RNA viruses. In this work, we demonstrate that tomato bushy stunt virus (TBSV) and the …

Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus with
the potential to infect humans. Accessory protein NS6, encoded by PDCoV, is a key factor …

The retromer complex (Vps35-Vps26-Vps29) is essential for endosomal membrane
trafficking and signaling. Mutation of the retromer subunit Vps35 causes late-onset …

Pan-genome analysis is a powerful method to explore genomic heterogeneity and diversity
of bacterial species. Here we present a pan-genome analysis of the genus Francisella …

Remodeling of host cellular membrane transport pathways is a common pathogenic trait of
many intracellular microbes that is essential to their intravacuolar life cycle and proliferation …

The Brucella species is the causative agent of brucellosis in humans and animals. So far,
brucellosis has caused considerable economic losses and serious public health threats …

Pathogens causing infections, and particularly when invading the host cells, require the host
cell machinery for efficient regeneration and proliferation during infection. For their life cycle …

CHAPTER ONE: INTRODUCTION Pathogenic bacteria with an intracellular lifecycle cause
many infectious diseases of great public health importance. They are globally distributed …