Cancer is a clonal disorder derived from a single ancestor cell and its progenies that are
positively selected by acquisition of 'driver mutations'. However, the evolution of positively …

Recent innovations in the next-generation sequencing technologies have unveiled that the
accumulation of genetic alterations results in the transformation of normal cells into cancer …

The progression of chronic liver disease to hepatocellular carcinoma is caused by the
acquisition of somatic mutations that affect 20–30 cancer genes,,,,,,–. Burdens of somatic …

The most common causes of chronic liver disease are excess alcohol intake, viral hepatitis
and non-alcoholic fatty liver disease, with the clinical spectrum ranging in severity from …

Inflammatory bowel disease (IBD) is a chronic inflammatory disease associated with
increased risk of gastrointestinal cancers. We whole-genome sequenced 446 colonic crypts …

Cancer is driven by genomic mutations in 'cancer driver'genes, which have essential roles in
tumor development. These mutations may be caused by exposure to mutagens in the …

Chronic liver disease and primary liver cancer are a massive global problem, with a future
increase in incidences predicted. The most prevalent form of primary liver cancer …

A research autopsy is a post-mortem medical procedure performed on a deceased
individual with the primary goal of collecting tissue to support basic and translational …

Telomerase regulation and telomere shortening act as a strong tumor suppressor
mechanism in human somatic cells. Point mutations in the promoter of telomerase reverse …

Hepatocellular carcinoma (HCC) is a global health issue and the fourth leading cause of
cancer deaths worldwide. Large-scale HCC genome sequencing analyses have identified …