The cornea, as a dynamic and responsive tissue, constantly interacts with mechanical forces
in order to maintain its structural integrity, barrier function, transparency and refractive …

The regeneration of dental pulp tissue is very important, but difficult, in dentistry. The
biocompatibility, water content, and viscoelastic properties of pulp-like tissue must be …

The extracellular matrix (ECM) is a noncellular structure that plays an indispensable role in a
series of cell life activities. Accumulating studies have demonstrated that ECM stiffness, a …

Mechanomimetic materials are particularly attractive for modeling in vitro fibroblast to
myofibroblast (Myof) transition, a key process in the physiological repair of damaged tissue …

Conjunctival fibrosis is a serious clinical concern implicated in a wide spectrum of eye
diseases, including outcomes of surgery for pterygium and glaucoma. It is mainly driven by …

Corneal transparency, necessary for vision and depending on the high organization of
stromal extracellular matrix, is maintained by keratocytes. Severe or continuous corneal …

Extracellular matrix (ECM) stiffness regulates development and homeostasis in vivo and
affects both physiological and pathological processes. A variety of studies have …

The switching of the fibroblast phenotype to myofibroblast is a hallmark of a wide variety of
tissue pathologies. This phenotypical switch is known to be influenced not only by humoral …

Corneal fibrosis is a common outcome of inappropriate repair associated with trauma or
ocular infection. Altered biomechanical properties with increased corneal stiffness is a …

After a stromal injury in the cornea, the release of growth factors and pro-inflammatory
cytokines typically results in the activation of quiescent keratocytes toward migratory …