Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus
Research in cellular mechanotransduction often focuses on how extracellular physical
forces are converted into chemical signals at the cell surface. However, mechanical forces …
forces are converted into chemical signals at the cell surface. However, mechanical forces …
The sperm nucleus: chromatin, RNA and the nuclear matrix
GD Johnson, C Lalancette… - Reproduction …, 2010 - pmc.ncbi.nlm.nih.gov
Within the sperm nucleus the paternal genome remains functionally inert and protected
following protamination. This is marked by a structural morphogenesis that is heralded by a …
following protamination. This is marked by a structural morphogenesis that is heralded by a …
Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture
Precise control of gene expression during differentiation relies on the interplay of chromatin
and nuclear structure. Despite an established contribution of nuclear membrane proteins to …
and nuclear structure. Despite an established contribution of nuclear membrane proteins to …
Nuclear matrix protein Matrin3 regulates alternative splicing and forms overlapping regulatory networks with PTB
Matrin3 is an RNA‐and DNA‐binding nuclear matrix protein found to be associated with
neural and muscular degenerative diseases. A number of possible functions of Matrin3 have …
neural and muscular degenerative diseases. A number of possible functions of Matrin3 have …
Chromosome territories and the global regulation of the genome
Spatial positioning is a fundamental principle governing nuclear processes. Chromatin is
organized as a hierarchy from nucleosomes to Mbp chromatin domains (CD) or topologically …
organized as a hierarchy from nucleosomes to Mbp chromatin domains (CD) or topologically …
Functional nuclear organization of transcription and DNA replication a topographical marriage between chromatin domains and the interchromatin compartment
We studied the nuclear topography of RNA transcription and DNA replication in mammalian
cell types with super-resolution fluorescence microscopy, which offers a resolution beyond …
cell types with super-resolution fluorescence microscopy, which offers a resolution beyond …
[HTML][HTML] Matrin 3 in neuromuscular disease: physiology and pathophysiology
AM Malik, SJ Barmada - JCI insight, 2021 - ncbi.nlm.nih.gov
RNA-binding proteins (RBPs) are essential factors required for the physiological function of
neurons, muscle, and other tissue types. In keeping with this, a growing body of genetic …
neurons, muscle, and other tissue types. In keeping with this, a growing body of genetic …
Characterization of the HIV-1 RNA associated proteome identifies Matrin 3 as a nuclear cofactor of Rev function
Background Central to the fully competent replication cycle of the human immunodeficiency
virus type 1 (HIV-1) is the nuclear export of unspliced and partially spliced RNAs mediated …
virus type 1 (HIV-1) is the nuclear export of unspliced and partially spliced RNAs mediated …
Effects of bisphenol A exposure on the proliferation and senescence of normal human mammary epithelial cells
XY Qin, T Fukuda, L Yang, H Zaha… - Cancer biology & …, 2012 - Taylor & Francis
The carcinogenic activity of bisphenol A (BPA) is responsible for stimulating growth in
estrogen-dependent breast cancer tissues, cell lines and rodent studies. However, it is not …
estrogen-dependent breast cancer tissues, cell lines and rodent studies. However, it is not …
Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndrome
DH Yasui, ML Gonzales, JO Aflatooni… - Human molecular …, 2014 - academic.oup.com
Mutations in MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT OMIM
312750). Alternative inclusion of MECP2/Mecp2 exon 1 with exons 3 and 4 encodes MeCP2 …
312750). Alternative inclusion of MECP2/Mecp2 exon 1 with exons 3 and 4 encodes MeCP2 …