Less than a decade ago, it was shown that bromodomains, acetyl lysine 'reader'modules
found in proteins with varied functions, were highly tractable small-molecule targets. This is …

Innate immunity serves as the rapid and first-line defense against invading pathogens, and
this process can be regulated at various levels, including epigenetic mechanisms. The …

Fungal infections in skin are extremely stubborn and seriously threaten human health. In the
process of antifungal treatment, it is a huge challenge that the stratum corneum of the skin …

Imidazo [1, 2‐a] pyridine is a well‐known scaffold in many marketed drugs, such as
Zolpidem, Minodronic acid, Miroprofen and DS‐1 and it also serves as a broadly applied …

Knowing the full set of essential genes for a given organism provides important information
about ways to promote, and to limit, its growth and survival. For many non-model organisms …

Breast cancer is susceptible to Candida infections, and candidiasis has an enhancing effect
on the progression and metastasis of tumor. Breast cancer and concurrent candidiasis …

Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

Bromodomain-containing proteins include bromodomain and extra-terminal (BET) and non-
BET families. Due to the conserved bromodomain (BD) module between BD-containing …

In recent years, incidences of invasive fungal infections have greatly increased, especially in
immunosuppressed patients, but most today's antifungal drugs are not completely effective …

Invasive fungal infections (IFIs) are emerging as a serious threat to public health and are
associated with high incidence and mortality. IFIs also represent a frequent complication in …