Bromodomains: a new target class for drug development
AG Cochran, AR Conery, RJ Sims III - Nature Reviews Drug Discovery, 2019 - nature.com
Less than a decade ago, it was shown that bromodomains, acetyl lysine 'reader'modules
found in proteins with varied functions, were highly tractable small-molecule targets. This is …
found in proteins with varied functions, were highly tractable small-molecule targets. This is …
[HTML][HTML] The BET family in immunity and disease
Innate immunity serves as the rapid and first-line defense against invading pathogens, and
this process can be regulated at various levels, including epigenetic mechanisms. The …
this process can be regulated at various levels, including epigenetic mechanisms. The …
Multifunctional parachute-like nanomotors for enhanced skin penetration and synergistic antifungal therapy
X Ji, H Yang, W Liu, Y Ma, J Wu, X Zong, P Yuan… - ACS …, 2021 - ACS Publications
Fungal infections in skin are extremely stubborn and seriously threaten human health. In the
process of antifungal treatment, it is a huge challenge that the stratum corneum of the skin …
process of antifungal treatment, it is a huge challenge that the stratum corneum of the skin …
The Groebke‐Blackburn‐Bienaymé Reaction
A Boltjes, A Dömling - European Journal of Organic Chemistry, 2019 - Wiley Online Library
Imidazo [1, 2‐a] pyridine is a well‐known scaffold in many marketed drugs, such as
Zolpidem, Minodronic acid, Miroprofen and DS‐1 and it also serves as a broadly applied …
Zolpidem, Minodronic acid, Miroprofen and DS‐1 and it also serves as a broadly applied …
Gene Essentiality Analyzed by In Vivo Transposon Mutagenesis and Machine Learning in a Stable Haploid Isolate of Candida albicans
Knowing the full set of essential genes for a given organism provides important information
about ways to promote, and to limit, its growth and survival. For many non-model organisms …
about ways to promote, and to limit, its growth and survival. For many non-model organisms …
BET–HDAC dual inhibitors for combinational treatment of breast cancer and concurrent candidiasis
Y Huang, N Liu, Z Pan, Z Li… - Journal of Medicinal …, 2023 - ACS Publications
Breast cancer is susceptible to Candida infections, and candidiasis has an enhancing effect
on the progression and metastasis of tumor. Breast cancer and concurrent candidiasis …
on the progression and metastasis of tumor. Breast cancer and concurrent candidiasis …
Unpacking the Pathogen Box—an open source tool for fighting neglected tropical disease
CGL Veale - ChemMedChem, 2019 - Wiley Online Library
Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …
their potential against several of the world's most important neglected tropical diseases …
Selectively targeting individual bromodomain: Drug discovery and molecular mechanisms
Q Wang, X Shao, ELH Leung, Y Chen, X Yao - Pharmacological Research, 2021 - Elsevier
Bromodomain-containing proteins include bromodomain and extra-terminal (BET) and non-
BET families. Due to the conserved bromodomain (BD) module between BD-containing …
BET families. Due to the conserved bromodomain (BD) module between BD-containing …
Potential targets for the development of new antifungal drugs
H Su, L Han, X Huang - The journal of antibiotics, 2018 - nature.com
In recent years, incidences of invasive fungal infections have greatly increased, especially in
immunosuppressed patients, but most today's antifungal drugs are not completely effective …
immunosuppressed patients, but most today's antifungal drugs are not completely effective …
Target-and prodrug-based design for fungal diseases and cancer-associated fungal infections
N Liu, J Tu, Y Huang, W Yang, Q Wang, Z Li… - Advanced Drug Delivery …, 2023 - Elsevier
Invasive fungal infections (IFIs) are emerging as a serious threat to public health and are
associated with high incidence and mortality. IFIs also represent a frequent complication in …
associated with high incidence and mortality. IFIs also represent a frequent complication in …