Mesenchymal stromal cell homing: mechanisms and strategies for improvement

M Ullah, DD Liu, AS Thakor - Iscience, 2019 - cell.com
Mesenchymal stromal cells (MSCs) have been widely investigated for their therapeutic
potential in regenerative medicine, owing to their ability to home damaged tissue and serve …

How to improve the survival of transplanted mesenchymal stem cell in ischemic heart?

L Li, X Chen, WE Wang, C Zeng - Stem Cells International, 2016 - Wiley Online Library
Mesenchymal stem cell (MSC) is an intensely studied stem cell type applied for cardiac
repair. For decades, the preclinical researches on animal model and clinical trials have …

Alternatively activated macrophages determine repair of the infarcted adult murine heart

M Shiraishi, Y Shintani, Y Shintani… - The Journal of …, 2016 - Am Soc Clin Investig
Alternatively activated (also known as M2) macrophages are involved in the repair of various
types of organs. However, the contribution of M2 macrophages to cardiac repair after …

All roads lead to Rome (the heart): cell retention and outcomes from various delivery routes of cell therapy products to the heart

J Li, S Hu, D Zhu, K Huang, X Mei… - Journal of the …, 2021 - Am Heart Assoc
In the past decades, numerous preclinical studies and several clinical trials have evidenced
the feasibility of cell transplantation in treating heart diseases. Over the years, different …

[HTML][HTML] Engineered cell-degradable poly (2-alkyl-2-oxazoline) hydrogel for epicardial placement of mesenchymal stem cells for myocardial repair

Y You, K Kobayashi, B Colak, P Luo, E Cozens… - Biomaterials, 2021 - Elsevier
Epicardial placement of mesenchymal stromal cells (MSCs) is a promising strategy for
cardiac repair post-myocardial infarction, but requires the design of biomaterials to maximise …

Stem cell death and survival in heart regeneration and repair

E Abdelwahid, A Kalvelyte, A Stulpinas… - Apoptosis, 2016 - Springer
Cardiovascular diseases are major causes of mortality and morbidity. Cardiomyocyte
apoptosis disrupts cardiac function and leads to cardiac decompensation and terminal heart …

Application of mesenchymal stem cell sheet to treatment of ischemic heart disease

D Chang, T Fan, S Gao, Y Jin, M Zhang… - Stem Cell Research & …, 2021 - Springer
In recent years, mesenchymal stem cells (MSCs) have been used to improve cardiac
function and attenuate adverse ventricular remodeling of the ischemic myocardium through …

Recent fabrications and applications of cardiac patch in myocardial infarction treatment

M Li, H Wu, Y Yuan, B Hu, N Gu - View, 2022 - Wiley Online Library
Myocardial infarction caused by coronary artery obstruction results in the loss of heart
muscle, which is subsequently replaced by scar tissue with limited therapeutic options …

Mending a broken heart: current strategies and limitations of cell-based therapy

LC Liew, BX Ho, BS Soh - Stem Cell Research & Therapy, 2020 - Springer
The versatility of pluripotent stem cells, attributable to their unlimited self-renewal capacity
and plasticity, has sparked a considerable interest for potential application in regenerative …

Mesenchymal stem/stromal cells and their paracrine activity—immunomodulation mechanisms and how to influence the therapeutic potential

R Alvites, M Branquinho, AC Sousa, B Lopes, P Sousa… - Pharmaceutics, 2022 - mdpi.com
With high clinical interest to be applied in regenerative medicine, Mesenchymal
Stem/Stromal Cells have been widely studied due to their multipotency, wide distribution …