Altered glutamatergic neurotransmission and neuronal metabolic dysfunction appear to be
central to the pathophysiology of Parkinson's disease (PD). The substantia nigra pars …

A model of basal ganglia functioning proposed a few years ago suggests that increased and
decreased activity in basal ganglia output to the thalamus underlies akinesia, as seen in …

High frequency stimulation (130 Hz) of the subthalamic nucleus has dramatic beneficial
motor effects in severe parkinsonian patients. However, the mechanisms underlying these …

High‐frequency stimulation (HFS) of the subthalamic nucleus (STN) proves to be an efficient
treatment for alleviating motor symptoms in Parkinson's disease (PD). However, the …

GABA and glutamate, the main transmitters in the basal ganglia, exert their effects through
ionotropic and metabotropic receptors. The dynamic activation of these receptors in …

Glutamatergic neurotransmission in the neostriatum and the globus pallidus is mediated
through NMDA‐type as well as other glutamate receptors and is critical in the expression of …

Abstract Changes in the neuronal activity of globus pallidus (GP) have been shown in
animal models of parkinsonism. In order to study the implication of the subthalamic nucleus …

In this study, the functional role of individual striatal receptors for adenosine (A2 AR),
dopamine (D2R), and the metabotropic glutamate receptor mG lu5R in regulating rat basal …

Glutamatergic neurotransmission in the substantia nigra pars compacta and pars reticulata
is mediated through N-methyl-d-aspartate and α-amino-3-hydroxy-5-methyl-4-isoxaline …

In the present study, we used dual-probe microdialysis to investigate the effects of
intrastriatal perfusion with neurotensin (NT) on striatal and pallidal glutamate and GABA …