Activity-dependent modifications in synaptic efficacy, such as long-term depression (LTD)
and long-term potentiation (LTP), represent key cellular substrates for adaptive motor control …

Since its first introduction, levodopa has become the cornerstone for the treatment of
Parkinson's disease and remains the leading therapeutic choice for motor control therapy so …

Abstract See Attems and Jellinger (doi: 10.1093/brain/awx360) for a scientific commentary
on this article. Cognitive changes occurring throughout the pathogenesis of …

The degeneration of nigral dopaminergic neurons is considered the hallmark of Parkinson's
disease (PD), and it is triggered by different factors, including mitochondrial dysfunction …

Parkinson's disease (PD) is a neurodegenerative disorder mainly characterized by a loss of
dopaminergic (DA) neurons in the substantia nigra pars compacta. In recent years, several …

Compelling evidences have shown that diverse environmental insults arising during early
life can either directly lead to a reduction in the number of dopaminergic neurons or cause …

Neuropathic pain, a chronic pain due to neuronal lesion, remains unaltered even after the
injury-induced spinal afferent discharges have declined, suggesting an involvement of …

Paraquat, the most well-known herbicides of toxicological class I, is widely used as an
effective herbicide despite its high toxicity for humans and animals. In the current research, a …

Paraquat (PQ), a widely used environmental toxin in agriculture, contributes to the onset and
progression of Parkinson's disease (PD) by damaging neurons. The JWA gene, also known …

Parkinson's disease (PD) is predominantly idiopathic in origin, and a large body of evidence
indicates that gastrointestinal (GI) dysfunctions are a significant comorbid clinical feature; …