Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …
more than 500 million population worldwide. OA was believed to be caused by the wearing …
Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease
The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …
[HTML][HTML] mTOR substrate phosphorylation in growth control
The target of rapamycin (TOR), discovered 30 years ago, is a highly conserved
serine/threonine protein kinase that plays a central role in regulating cell growth and …
serine/threonine protein kinase that plays a central role in regulating cell growth and …
Regulation and metabolic functions of mTORC1 and mTORC2
Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …
PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers
R Liu, Y Chen, G Liu, C Li, Y Song, Z Cao, W Li… - Cell death & …, 2020 - nature.com
Multidrug resistance (MDR) is the dominant challenge in the failure of chemotherapy in
cancers. Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that spreads intracellular …
cancers. Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that spreads intracellular …
mTOR signalling and cellular metabolism are mutual determinants in cancer
D Mossmann, S Park, MN Hall - Nature Reviews Cancer, 2018 - nature.com
Oncogenic signalling and metabolic alterations are interrelated in cancer cells. mTOR,
which is frequently activated in cancer, controls cell growth and metabolism. mTOR …
which is frequently activated in cancer, controls cell growth and metabolism. mTOR …
[HTML][HTML] The PI3K/AKT pathway in obesity and type 2 diabetes
X Huang, G Liu, J Guo, Z Su - International journal of biological …, 2018 - ncbi.nlm.nih.gov
Obesity and type 2 diabetes mellitus are complicated metabolic diseases that affect multiple
organs and are characterized by hyperglycaemia. Currently, stable and effective treatments …
organs and are characterized by hyperglycaemia. Currently, stable and effective treatments …
mTOR signaling in cancer and mTOR inhibitors in solid tumor targeting therapy
T Tian, X Li, J Zhang - International journal of molecular sciences, 2019 - mdpi.com
The mammalian or mechanistic target of rapamycin (mTOR) pathway plays a crucial role in
regulation of cell survival, metabolism, growth and protein synthesis in response to upstream …
regulation of cell survival, metabolism, growth and protein synthesis in response to upstream …
mTOR: Role in cancer, metastasis and drug resistance
AK Murugan - Seminars in cancer biology, 2019 - Elsevier
Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that gets inputs from
the amino acids, nutrients, growth factor, and environmental cues to regulate varieties of …
the amino acids, nutrients, growth factor, and environmental cues to regulate varieties of …
The PI3K pathway in human disease
DA Fruman, H Chiu, BD Hopkins, S Bagrodia… - Cell, 2017 - cell.com
Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth
factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K …
factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K …