The RNA World: molecular cooperation at the origins of life
PG Higgs, N Lehman - Nature Reviews Genetics, 2015 - nature.com
The RNA World concept posits that there was a period of time in primitive Earth's history—
about 4 billion years ago—when the primary living substance was RNA or something …
about 4 billion years ago—when the primary living substance was RNA or something …
Ecology and evolution in the RNA world dynamics and stability of prebiotic replicator systems
As of today, the most credible scientific paradigm pertaining to the origin of life on Earth is
undoubtedly the RNA World scenario. It is built on the assumption that catalytically active …
undoubtedly the RNA World scenario. It is built on the assumption that catalytically active …
Emergence of light-driven protometabolism on recruitment of a photocatalytic cofactor by a self-replicator
Establishing how life can emerge from inanimate matter is among the grand challenges of
contemporary science. Chemical systems that capture life's essential characteristics …
contemporary science. Chemical systems that capture life's essential characteristics …
Origins of life: a problem for physics, a key issues review
SI Walker - Reports on Progress in Physics, 2017 - iopscience.iop.org
The origins of life stands among the great open scientific questions of our time. While a
number of proposals exist for possible starting points in the pathway from non-living to living …
number of proposals exist for possible starting points in the pathway from non-living to living …
Universal sequence replication, reversible polymerization and early functional biopolymers: a model for the initiation of prebiotic sequence evolution
Many models for the origin of life have focused on understanding how evolution can drive
the refinement of a preexisting enzyme, such as the evolution of efficient replicase activity …
the refinement of a preexisting enzyme, such as the evolution of efficient replicase activity …
Evolutionary game theory: molecules as players
K Bohl, S Hummert, S Werner, D Basanta… - Molecular …, 2014 - pubs.rsc.org
In this and an accompanying paper we review the use of game theoretical concepts in cell
biology and molecular biology. This review focuses on the subcellular level by considering …
biology and molecular biology. This review focuses on the subcellular level by considering …
Metabolically Coupled Replicator Systems: Overview of an RNA-world model concept of prebiotic evolution on mineral surfaces
Abstract Metabolically Coupled Replicator Systems (MCRS) are a family of models
implementing a simple, physico-chemically and ecologically feasible scenario for the first …
implementing a simple, physico-chemically and ecologically feasible scenario for the first …
On the origin of biomolecular networks
Biomolecular networks have already found great utility in characterizing complex biological
systems arising from pairwise interactions amongst biomolecules. Here, we explore the …
systems arising from pairwise interactions amongst biomolecules. Here, we explore the …
Spatial aspects of prebiotic replicator coexistence and community stability in a surface-bound RNA world model
Background The coexistence of macromolecular replicators and thus the stability of
presumed prebiotic replicator communities have been shown to critically depend on …
presumed prebiotic replicator communities have been shown to critically depend on …
Computer simulation on the cooperation of functional molecules during the early stages of evolution
W Ma, J Hu - PLoS One, 2012 - journals.plos.org
It is very likely that life began with some RNA (or RNA-like) molecules, self-replicating by
base-pairing and exhibiting enzyme-like functions that favored the self-replication. Different …
base-pairing and exhibiting enzyme-like functions that favored the self-replication. Different …