Limited drug delivery to the brain is one of the major reasons for high failure rates of central
nervous system (CNS) drug candidates. The blood–brain barrier (BBB) with its tight …

Introduction: Drug targeting to brain by circumventing the physiological barriers is a
prerequisite for drugs acting on central nervous system (CNS) and therapeutic potential of …

Smoking is a documented risk factor for cancer, eg, gastric cancer. Nicotine, the principal
tobacco alkaloid, would exert its role of contribution to gastric cancer development and …

The deleterious effects of the drug addiction epidemic are compounded by treatment
strategies that are only marginally efficacious. Memantine is a unique glutamatergic …

Bioaugmentation (BA) using Acinetobacter sp. TW with high nicotine-degrading efficiency
was applied in a bioreactor receiving a load of COD (3200±50mg/L) and nicotine (1.0±0.1 …

Abstract The School of Pharmacy and Pharmaceutical Sciences at Trinity College Dublin
hosted the “1 st Workshop on Drug Transporters in the Lungs” in September 2016 to discuss …

Tramadol is a centrally acting analgesic whose action is mediated by both agonistic activity
at opioid receptors and inhibitory activity on neuronal reuptake of monoamines. The purpose …

Abstract The European Food Safety Authority asked the Panel on Plant Protection Products
(PPR) and their residues to deliver a Scientific Opinion on the developmental neurotoxicity …

Nicotine, an addictive substance, is absorbed from the lungs following inhalation of tobacco
smoke, and distributed to various tissues such as liver, brain, and retina. Recent in vivo and …

Memantine is clinically used for the treatment of patients with Alzheimer's disease and is
highly distributed to the brain. The aim of this study is to characterize memantine transport at …