Background Metabolic reprogramming is a major feature of many tumors including non-
small cell lung cancer (NSCLC). Branched-chain α-keto acid dehydrogenase kinase …

ATM is a key mediator of radiation response, and pharmacological inhibition of ATM is a
rational strategy to radiosensitize tumors. AZD1390 is a brain-penetrant ATM inhibitor and a …

In the past few years, various somatic point mutations of isocitrate dehydrogenase (IDH)
encoding genes (IDH1 and IDH2) have been identified in a broad range of cancers …

Objective Because of their rarity, it is not known whether isocitrate dehydrogenase 2 (IDH2)
mutations are related to the occurrence of olfactory neuroblastoma (ONB). We investigated …

Background: Gliomas are neoplasms of the central nervous system that originate in glial
cells. The genetic characteristics of this type of neoplasm are the loss of function of tumor …

Diffuse gliomas are growing brain tumors that occur in adult life. This study was designed to
determine whether the immunohistochemical analysis of IDH1, HIF-1alpha, or TP53 can …

Low-grade glioma is the most common type of primary intracranial tumor. In the last 3 years,
new observations of molecular precursors in adults with gliomas have led to a modification …

Background Cancer driver genes are usually ranked by mutation frequency, which does not
necessarily reflect their driver strength. We hypothesize that driver strength is higher for …

Low-grade gliomas are the most common primary brain tumors which affects the central
nervous system (CNS), they causes considerable morbidity and represents a therapeutic …

Objective: To compare the frequency of expression of p53 in different grades of glioma.
Methodology: This descriptive, cross-sectional study was conducted at Pakistan Institute of …