Selective targeting of the DEAD-box RNA helicase eukaryotic initiation factor (eIF) 4A by natural products
L Shen, J Pelletier - Natural product reports, 2020 - pubs.rsc.org
Covering: up to 2019 Pharmacological targeting of eukaryotic mRNA translation initiation is
a promising approach for cancer therapy, since several signaling pathways that are …
a promising approach for cancer therapy, since several signaling pathways that are …
Targeting translation of mRNA as a therapeutic strategy in cancer
Abstract Purpose of Review To highlight recent results in targeting mRNA translation and
discuss the results and prospects of translation inhibitors in cancer therapy. Recent Findings …
discuss the results and prospects of translation inhibitors in cancer therapy. Recent Findings …
[HTML][HTML] Functional mimicry revealed by the crystal structure of an eIF4A: RNA complex bound to the interfacial inhibitor, desmethyl pateamine A
SK Naineni, J Liang, K Hull, R Cencic, M Zhu… - Cell chemical …, 2021 - cell.com
Interfacial inhibitors exert their biological effects through co-association with two
macromolecules. The pateamine A (PatA) class of molecules function by stabilizing …
macromolecules. The pateamine A (PatA) class of molecules function by stabilizing …
[HTML][HTML] Targeted inhibition of eIF4A suppresses B-cell receptor-induced translation and expression of MYC and MCL1 in chronic lymphocytic leukemia cells
S Wilmore, KR Rogers-Broadway, J Taylor… - Cellular and Molecular …, 2021 - Springer
Signaling via the B-cell receptor (BCR) is a key driver and therapeutic target in chronic
lymphocytic leukemia (CLL). BCR stimulation of CLL cells induces expression of eIF4A, an …
lymphocytic leukemia (CLL). BCR stimulation of CLL cells induces expression of eIF4A, an …
[HTML][HTML] Cyclin-dependent kinase inhibitor fadraciclib (CYC065) depletes anti-apoptotic protein and synergizes with venetoclax in primary chronic lymphocytic …
R Chen, Y Chen, P Xiong, D Zheleva, D Blake… - Leukemia, 2022 - nature.com
Fadraciclib (CYC065) is a second-generation aminopurine CDK2/9 inhibitor with increased
potency and selectivity toward CDK2 and CDK9 compared to seliciclib (R-roscovitine). In …
potency and selectivity toward CDK2 and CDK9 compared to seliciclib (R-roscovitine). In …
[HTML][HTML] DMDA-PatA mediates RNA sequence-selective translation repression by anchoring eIF4A and DDX3 to GNG motifs
H Saito, Y Handa, M Chen… - Nature …, 2024 - nature.com
Small-molecule compounds that elicit mRNA-selective translation repression have attracted
interest due to their potential for expansion of druggable space. However, only a limited …
interest due to their potential for expansion of druggable space. However, only a limited …
[HTML][HTML] The multi-kinase inhibitor TG02 induces apoptosis and blocks B-cell receptor signaling in chronic lymphocytic leukemia through dual mechanisms of action
R Chen, J Tsai, PA Thompson, Y Chen, P Xiong… - Blood cancer …, 2021 - nature.com
The constitutive activation of B-cell receptor (BCR) signaling, together with the
overexpression of the Bcl-2 family anti-apoptotic proteins, represents two hallmarks of …
overexpression of the Bcl-2 family anti-apoptotic proteins, represents two hallmarks of …
[HTML][HTML] eIF4A/PDCD4 pathway, a factor for doxorubicin chemoresistance in a triple-negative breast cancer cell model
A González-Ortiz, A Pulido-Capiz… - Cells, 2022 - mdpi.com
Cells employ several adaptive mechanisms under conditions of accelerated cell division,
such as the unfolded protein response (UPR). The UPR is composed of a tripartite signaling …
such as the unfolded protein response (UPR). The UPR is composed of a tripartite signaling …
Chemical synthesis as a discovery platform in immunosuppression and determination of mode of action
Over the past century, the use of organ transplantation to replace malfunctioning tissue has
leapt from an impossibility to being a routine procedure. This development has hinged on …
leapt from an impossibility to being a routine procedure. This development has hinged on …
[HTML][HTML] Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome
Tactical disruption of protein synthesis is an attractive therapeutic strategy, with the first-in-
class eIF4A-targeting compound zotatifin in clinical evaluation for cancer and COVID-19 …
class eIF4A-targeting compound zotatifin in clinical evaluation for cancer and COVID-19 …